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Waist circumference-dependent peripheral monocytes change after gliclazide treatment for Chinese type 2 diabetic patients

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Summary

Gliclazide used for the treatment of type 2 diabetes mellitus (T2DM) stimulates insulin secretion and influences peripheral blood monocytes. The roles of gliclazide in peripheral monocytes of newly diagnosed T2DM patients were investigated in this study. A total of 105 newly diagnosed T2DM patients with no history of antihyperglycemic medication were treated with gliclazide-modified release for 16 weeks. The total and differential leukocyte profiles of peripheral blood were measured at baseline and week 16. The peripheral blood monocyte count at week 16 was significantly lower than that at baseline (P=0.019). Peripheral monocytes level at baseline was positively correlated with waist circumference. After gliclazide treatment, the peripheral monocytes were decreased [(320.09±15.13)×106/L vs. (294.19±14.22)×106/L] in non-abdominal obesity group, but increased in abdominal obesity group [(344.36±17.24)×106/L vs. (351.87±16.93)×106/L]. Compared with non-abdominal obese patients, abdominal obese patients showed higher Δmonocytes (P=0.046) and Δacute insulin secretion (P=0.049), but lower ΔHbA1c (P=0.047). There was significantly positive correlation between Δmonocytes and Δacute insulin secretion (P=0.015), which disappeared after adjusting for age, waist circumference and dosage at baseline. In conclusion, waist circumference is correlated with peripheral monocyte change after gliclazide treatment in Chinese newly diagnosed T2DM patients. Peripheral monocytes are decreased in non-abdominal obesity group and increased in abdominal obesity group after gliclazide treatment.

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Acknowledgments

We thank the individuals who participated in the present study. We gratefully acknowledge the skillful technical support of all the nursing and medical staff at the Shanghai Clinical Center for Diabetes.

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Authors and Affiliations

  1. Department of Endocrinology & Metabolism, Shanghai Clinical Center of Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China

    Qing Li  (李 青), Hao-yong Yu  (于浩泳), Miao Chen  (陈 淼), Feng Jiang  (江 枫), Jian Zhou  (周 健), Yu-qian Bao  (包玉倩), Cheng Hu  (胡 承) & Wei-ping Jia  (贾伟平)

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  1. Qing Li  (李 青)
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  2. Hao-yong Yu  (于浩泳)
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  3. Miao Chen  (陈 淼)
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  4. Feng Jiang  (江 枫)
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  5. Jian Zhou  (周 健)
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  6. Yu-qian Bao  (包玉倩)
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  7. Cheng Hu  (胡 承)
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  8. Wei-ping Jia  (贾伟平)
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Corresponding authors

Correspondence to Cheng Hu  (胡 承) or Wei-ping Jia  (贾伟平).

Additional information

Both authors contributed equally to this work.

This work was supported by 973 Program (No. 2011CB504001), the National Natural Science Foundation of China (Nos. 81322010, 81170735 and 81200582), the Drug Innovation Program of the National Science and Technology Project (No. 2011ZX09307-001-02), 863 Program (No. 2012AA02A509), Excellent Young Medical Expert of Shanghai (No. XYQ2011041), Shanghai Talent Development Grant (No. 2012041) and National Young Top Talent Supporting Program.

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Li, Q., Yu, Hy., Chen, M. et al. Waist circumference-dependent peripheral monocytes change after gliclazide treatment for Chinese type 2 diabetic patients. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 37, 204–209 (2017). https://doi.org/10.1007/s11596-017-1716-x

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  • DOI: https://doi.org/10.1007/s11596-017-1716-x

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