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Effects of Bu-Shen-An-Tai recipe and its two components on endometrial morphology during peri-implantation in superovulated mice

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Summary

The aim of this study was to investigate the effect of Bu-Shen-An-Tai recipe (BSATR) and its two components (Bushen recipe, and Huoxue recipe) on endometrial morphology during peri-implantation in superovulated mice. Mice were randomly divided into five groups, including the normal (N), model (M), Bushen (BS), Huoxue (HX) and Bu-Shen-An-Tai (BH) groups. The uteri were collected on day 4 of pregnancy, and the endometrium thickness, microvessel density (MVD) and number of pinopodes observed. Compared with the M group, the endometrial thickness in the BS, HX and BH groups was significantly increased and there was a significant difference in endometrial thickness between the BS and the BH groups. The mean MVD was significantly lower in the M group than in the N group, and there was a significant increase in MVD in the BS, HX and BH groups as compared with the M group. Compared with the M group, the pinopode scores in the endometrium were significantly increased in the HX and BH groups; and the BS group had significantly higher pinipode scores than the HX and BH groups. In conclusion, the results of the present study demonstrated that the recipes (Bushen, Huoxue and BSATR) could improve the endometrial environment by regulating the endometrial thickness, MVD and the number of pinopodes at the window of implantation. Moreover, the Huoxue recipe and the BSATR were more efficient than the Bushen recipe, with the BSATR tending to have the most beneficial effects.

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Authors and Affiliations

  1. Institute of Integrated Traditional Chinese and Western Medicine, Huazhong University of Science and Technology, Wuhan, 430030, China

    Dan-dan Cui  (崔丹丹), Cui-hong Zheng  (郑翠红), Lu Wen  (文 露) & Wen-wen Ma  (马雯雯)

  2. Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Ping Gong  (龚 萍) & Ming-min Zhang  (张明敏)

  3. Center of Experimental Animals, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Shun-chang Zhou  (周顺长)

Authors
  1. Dan-dan Cui  (崔丹丹)
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  4. Lu Wen  (文 露)
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Correspondence to Ming-min Zhang  (张明敏).

Additional information

This project was supported by the National Natural Science Foundation of China (No. 30873347).

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Cui, Dd., Zheng, Ch., Gong, P. et al. Effects of Bu-Shen-An-Tai recipe and its two components on endometrial morphology during peri-implantation in superovulated mice. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 34, 768–774 (2014). https://doi.org/10.1007/s11596-014-1350-9

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  • DOI: https://doi.org/10.1007/s11596-014-1350-9

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