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Influence of blastocysts morphological score on pregnancy outcomes in frozen-thawed blastocyst transfers: a retrospective study of 741 cycles

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Summary

The influence of inner cell mass (ICM) and trophectoderm (TE) score on pregnancy outcomes in frozen-thawed blastocyst transfer cycles was analyzed. A retrospective analysis of 741 cycles of frozen-thawed blastosysts transfer was performed. All cycles were divided into four groups based on the number and morphological score of blastocysts: S-ICM B/TE B group (n=91), the single blastocyst transfer of ICM B and TE B; D-ICM B/TE B group (n=579), double blastocysts transfer of ICM B/TE B; D-ICM B/TE C group (n=35), double blastocysts transfer of ICM B/TE C; and D-ICM C/TE B group (n=36), double blastocysts transfer of TE B/ICM C. The pregnancy outcomes were compared among the four groups. As compared with D-ICM B/TE C group, the clinical pregnancy rate, implantation rate and multiple pregnancy rate were increased in D-ICM B/TE B group (74.96% vs. 57.14%, 57.43% vs. 37.14%, and 48.62% vs. 25%, respectively, P<0.05 for all). Clinical pregnancy rate and implantation rate in D-ICM B/TE B group were also higher than in D-ICM C/TE B group (74.96% vs. 50%, and 57.43% vs. 33.33%, both P<0.05). Multivariable Logistic regression analysis indicated that ICM score was a better predictive parameter for clinical pregnancy (OR=3.05, CI 1.70–5.46, P<0.001), while the trophectoderm score was a better one for early abortion (OR=0.074, CI 0.03–0.19, P<0.001). Clinical pregnancy rate and multiple pregnancy rate in S-ICM B/TE B group were significantly lower than those in D-ICM B/TE B group (46.15% vs. 74.96%, and 2.38% vs. 48.62%, both P<0.05), but there was no significant difference in the implantation rate between the two groups. It was suggested that the higher score of ICM and TE may be indicative of the better pregnancy outcomes. The ICM score is a better predictor of clinical pregnancy than TE, while TE score is a better one in predicting early abortion. Single ICM B/TE B blastocyst transfer in frozen-thawed cycles can also get satisfactory pregnancy outcomes.

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Authors and Affiliations

  1. Reproductive Medical Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Lin Liu  (刘 琳), Yan-hui Li  (李艳辉), Xiao-fang Ding  (丁晓芳), Yu-hong Geng  (耿育红), Chun-yan Chen  (陈春艳) & Ying Gao  (高 颖)

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  1. Lin Liu  (刘 琳)
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  2. Yan-hui Li  (李艳辉)
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  3. Xiao-fang Ding  (丁晓芳)
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  4. Yu-hong Geng  (耿育红)
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  5. Chun-yan Chen  (陈春艳)
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  6. Ying Gao  (高 颖)
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Correspondence to Ying Gao  (高 颖).

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The authors contributed equally to this work.

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Liu, L., Li, Yh., Ding, Xf. et al. Influence of blastocysts morphological score on pregnancy outcomes in frozen-thawed blastocyst transfers: a retrospective study of 741 cycles. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 34, 750–754 (2014). https://doi.org/10.1007/s11596-014-1347-4

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  • DOI: https://doi.org/10.1007/s11596-014-1347-4

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