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Association between CHRNA3 rs1051730 genotype and lung cancer risk in Chinese Han population: A case-control study

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Summary

Recent population-based genome wide association studies have revealed potential susceptibility loci of lung cancer at the region of chromosome 15q25.1 containing nicotinic acetylcholine receptor genes. The loci increasing lung cancer risk has been widely identified in Caucasians, but whether this association also exists in Asians and whether this association is a direct role or mediated via tobacco smoking indirectly has not been fully established. We conducted a case-control study comprising of 210 histologically confirmed lung cancer cases and 200 healthy controls to examine rs1051730 genotyping, a single nucleotide polymorphism receiving much attention recently, and its influence on lung cancer risk as well as nicotine dependence in a Chinese Han population. Our results showed that the heterozygous C/T genotype and minor allele T conferred a significant higher risk of lung cancer than the CC homozygotes and allele C (adjusted OR=2.25, 95% CI=1.04–4.89, P=0.040 and OR=2.18, 95% CI=1.02–4.67, P=0.045 respectively). However, no association between the smoking habit and the CHRNA3 rs1051730 polymorphism was observed in this study. The results suggested that the rs1051730 polymorphism may modify susceptibility to lung cancer via a smoking-independent manner among Chinese Han population. Additional studies in vitro and in vivo are warranted to further elucidate the impact of rs1051730 on lung cancer susceptibility.

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Authors and Affiliations

  1. Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China

    Jing-hua Ren  (任精华), Min Jin  (金 敏), Cui-wei Liu  (刘翠微), Shun Jiang  (蒋 顺), Wei-hong Chen  (陈卫红), Kun-yu Yang  (杨坤禹), Gang Wu  (伍 钢) & Tao Zhang  (张 涛)

  2. Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Wen-shan He  (何文山)

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  1. Jing-hua Ren  (任精华)
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  2. Min Jin  (金 敏)
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  3. Wen-shan He  (何文山)
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  4. Cui-wei Liu  (刘翠微)
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  5. Shun Jiang  (蒋 顺)
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  6. Wei-hong Chen  (陈卫红)
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  7. Kun-yu Yang  (杨坤禹)
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  8. Gang Wu  (伍 钢)
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  9. Tao Zhang  (张 涛)
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Correspondence to Tao Zhang  (张 涛).

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The authors contributed equally to this work.

This project was supported by the National Natural Science Foundation of China (No. 81372712).

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Ren, Jh., Jin, M., He, Ws. et al. Association between CHRNA3 rs1051730 genotype and lung cancer risk in Chinese Han population: A case-control study. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 33, 897–901 (2013). https://doi.org/10.1007/s11596-013-1218-4

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  • DOI: https://doi.org/10.1007/s11596-013-1218-4

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