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Cumulative live birth rate after three ovarian stimulation IVF cycles for poor ovarian responders according to the bologna criteria

Journal of Huazhong University of Science and Technology [Medical Sciences] volume 33, pages 418–422 (2013)Cite this article

Summary

This study explored the cumulative live birth rate after three ovarian stimulation in vitro fertilization (IVF) cycles for poor ovarian responders according to the Bologna criteria. In this retrospective cohort study, 479 poor ovarian responders according to the Bologna criteria in the first ovarian stimulation IVF cycle between July 2006 and January 2012 in our IVF centre were included. The cumulative live birth rate was calculated by optimistic and pessimistic methods. The cumulative live birth rate after three ovarian stimulation IVF cycles for poor ovarian responders according to the Bologna criteria was 12.7%–20.5%. The three-cycle cumulative live birth rate was 18.5%–24.5%, 13.2%–27.4% and 8.6%–14.9% for poor responders aged ≤35 years, 36–39 years and ≥40 years, respectively. In conclusion, poor responders according to the Bologna criteria can receive an acceptable cumulative live birth rate after three ovarian stimulation IVF cycles, especially poor responders aged <40 years.

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References

  1. Healy DL, Okamato S, Morrow L, et al. Contributions of in vitro fertilization to knowledge of the reproductive endocrinology of the menstrual cycle. Baillieres Clin Endocrinol Metab, 1987,1(1):133–152

    PubMed  Article  CAS  Google Scholar 

  2. Jennings JC, Moreland K, Peterson CM. In vitro fertilisation. A review of drug therapy and clinical management. Drugs, 1996,52(3):313–343

    PubMed  Article  CAS  Google Scholar 

  3. Ulug U, Ben-Shlomo I, Turan E, et al. Conception rates following assisted reproduction in poor responder patients: a retrospective study in 300 consecutive cycles. Reprod Biomed Online, 2003,6(4):439–443

    PubMed  Article  Google Scholar 

  4. Biljan MM, Buckett WM, Dean N, et al. The outcome of IVF-embryo transfer treatment in patients who develop three follicles or less. Hum Reprod, 2000,15(10): 2140–2144

    PubMed  Article  CAS  Google Scholar 

  5. De Sutter P, Dhont M. Poor response after hormonal stimulation for in vitro fertilization is not related to ovarian aging. Fertil Steril, 2003,79(6):1294–1298

    PubMed  Article  Google Scholar 

  6. Inge GB, Brinsden PR, Elder KT. Oocyte number per live birth in IVF: were Steptoe and Edwards less wasteful? Hum Reprod, 2005,20(3):588–592

    PubMed  Article  Google Scholar 

  7. Veleva Z, Jarvela IY, Nuojua-Huttunen S, et al. An initial low response predicts poor outcome in in vitro fertilization/intracytoplasmic sperm injection despite improved ovarian response in consecutive cycles. Fertil Steril, 2005,83(5):1384–1390

    PubMed  Article  Google Scholar 

  8. Hendriks DJ, te Velde ER, Looman CW, et al. Expected poor ovarian response in predicting cumulative pregnancy rates: a powerful tool. Reprod Biomed Online, 2008,17(5):727–736

    PubMed  Article  Google Scholar 

  9. Orvieto R, Meltcer S, Nahum R, et al. The influence of body mass index on in vitro fertilization outcome. Int J Gynaecol Obstet, 2009,104(1):53–55

    PubMed  Article  Google Scholar 

  10. Ferraretti AP, La Marca A, Fauser BC, et al. ESHRE consensus on the definition of’ poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod, 2011,26(7):1616–1624

    PubMed  Article  CAS  Google Scholar 

  11. Polyzos NP, Devroey P. A systematic review of randomized trials for the treatment of poor ovarian responders: is there any light at the end of the tunnel? Fertil Steril, 2011,96(5):1058–1061

    PubMed  Article  Google Scholar 

  12. Polyzos NP, Blockeel C, Verpoest W, et al. Live birth rates following natural cycle IVF in women with poor ovarian response according to the Bologna criteria. Hum Reprod, 2012,27(12):3481–3486

    PubMed  Article  CAS  Google Scholar 

  13. Lainas TG, Sfontouris IA, Zorzovilis IZ, et al. Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT). Hum Reprod, 2010,25(3):683–689

    PubMed  Article  CAS  Google Scholar 

  14. Stolwijk AM, Hamilton CJ, Hollanders JM, et al. A more realistic approach to the cumulative pregnancy rate after in-vitro fertilization. Hum Reprod, 1996,11(3):660–663

    PubMed  Article  CAS  Google Scholar 

  15. Olivius K, Friden B, Lundin K, et al. Cumulative probability of live birth after three in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril, 2002,77(3):505–510

    PubMed  Article  Google Scholar 

  16. Saldeen P, Kallen K, Sundstrom P. The probability of successful IVF outcome after poor ovarian response. Acta Obstet Gynecol Scand, 2007,86(4):457–461

    PubMed  Article  Google Scholar 

  17. Timeva T, Milachich T, Antonova I, et al. Correlation between number of retrieved oocytes and pregnancy rate after in vitro fertilization/intracytoplasmic sperm infection. Sci World J, 2006,6:686–690

    Article  Google Scholar 

  18. Zhen XM, Qiao J, Li R, et al. The clinical analysis of poor ovarian response in in-vitro-fertilization embryo-transfer among Chinese couples. J Assist Reprod Genet, 2008,25(1):17–22

    PubMed  Article  CAS  Google Scholar 

  19. Maman E, Geva LL, Yerushalmi G, et al. ICSI increases ongoing pregnancy rates in patients with poor response cycle: multivariate analysis of 2819 cycles. Reprod Biomed Online, 2012,25(6):635–641

    PubMed  Article  Google Scholar 

  20. Hanoch J, Lavy Y, Holzer H, et al. Young low responders protected from untoward effects of reduced ovarian response. Fertil Steril, 1998,69(6):1001–1004

    PubMed  Article  CAS  Google Scholar 

  21. Galey-Fontaine J, Cedrin-Durnerin I, Chaibi R, et al. Age and ovarian reserve are distinct predictive factors of cycle outcome in low responders. Reprod Biomed Online, 2005,10(1):94–99

    PubMed  Article  Google Scholar 

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Affiliations

  1. Centre for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

    Hui Ke, Xin Chen, Yu-dong Liu, De-sheng Ye, Yu-xia He & Shi-ling Chen

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  1. Hui Ke
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  2. Xin Chen
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  3. Yu-dong Liu
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  4. De-sheng Ye
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  5. Yu-xia He
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  6. Shi-ling Chen
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Corresponding author

Correspondence to Shi-ling Chen.

Additional information

These authors contributed equally to this work.

This project was supported by grants from Comprehensive Strategic Sciences Cooperation Projects of Guangdong Province and Chinese Academy (No. 2010B090301026), Guangzhou Science and Technology Program Key Projects (No. 11C22120737), National Natural Science Foundation of China (No. 81170574) and Scientific Research Plan of Southern Medical University.

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Ke, H., Chen, X., Liu, Yd. et al. Cumulative live birth rate after three ovarian stimulation IVF cycles for poor ovarian responders according to the bologna criteria. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 33, 418–422 (2013). https://doi.org/10.1007/s11596-013-1134-7

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  • DOI: https://doi.org/10.1007/s11596-013-1134-7

Key words

  • ovarian stimulation
  • in vitro fertilization
  • Bologna criteria
  • poor responders
  • cumulative live birth