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Mannose-binding lectin two gene polymorphisms and tuberculosis susceptibility in Chinese population: A meta-analysis

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Summary

Numerous studies have been done to explore the association between mannose-binding lectin two (MBL2) gene polymorphisms and the risk of tuberculosis (TB). However, the results are inconsistent. We performed a meta-analysis to investigate whether polymorphisms in the MBL2 gene were associated with TB risk. Databases including PubMed, Medline, Chinese Biomedicine Database, China National Knowledge Infrastructure, Wanfang Database, and Weipu Database were searched to find relevant articles published up to 2 October, 2012. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of association. All statistical tests were performed by using Revman 5.1 software and STATA 11.0 software. Six case-control studies including 1106 cases and 1190 controls were accepted in the meta-analysis. The results indicated that individuals carrying the MBL2 codon 54 B allele may have an increased risk of TB as compared with AA homozygotes (BB+AB vs. AA: OR=1.52, 95% CI: 1.22–1.88), whereas MBL2 +4 P/Q was possibly not associated with TB susceptibility in Chinese population.

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References

  1. WHO (2011) Global tuberculosis control: WHO report 2011. Geneva: WHO. WHO/HTM/TB/2011.16. (Accessed October 13, 2012 at http://www.who.int/tb/publications/global_report/en/.

    Google Scholar 

  2. Zhang Y, Zhang J, Zeng L, et al. The -2518A/G polymorphism in the MCP-1 gene and tuberculosis risk: a meta-analysis. PLoS One, 2012,7(7):e38918

    Article  PubMed  CAS  Google Scholar 

  3. Turner MW. Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol Today, 1996,17(11):532–540

    PubMed  CAS  Google Scholar 

  4. Lee YH, Witte T, Momot T, et al. The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis. Arthritis Rheum, 2005,52(12):3966–3974

    Article  PubMed  CAS  Google Scholar 

  5. Gupta K, Gupta RK, Hajela K, et al. Disease associations of mannose-binding lectin & potential of replacement therapy. Indian J Med Res, 2008,127(5):431–440

    PubMed  CAS  Google Scholar 

  6. Heitzeneder S, Seidel M, Förster-Waldl E, et al. Mannan-binding lectin deficiency-Good news, bad news, doesn’t matter? Clin Immunol, 2012,143(1):22–38

    Article  PubMed  CAS  Google Scholar 

  7. Madsen HO, Satz ML, Hogh B, et al. Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America. J Immunol, 1998,161(6):3169–3175

    PubMed  CAS  Google Scholar 

  8. Selvaraj P, Narayanan PR, Reetha AM. Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India. Tuber Lung Dis, 1999,79(4):221–227

    Article  PubMed  CAS  Google Scholar 

  9. Bellamy R. Identifying genetic susceptibility factors for tuberculosis in Africans: a combined approach using a candidate gene study and a genome-wide screen. Clin Sci (Lond), 2000,98(3):245–250

    Article  CAS  Google Scholar 

  10. Mombo LE, Lu CY, Ossari S, et al. Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections. Genes Immun, 2003,4(5):362–367

    Article  PubMed  CAS  Google Scholar 

  11. Druszczyńska M, Strapagiel D, Kwiatkowska S, et al. Tuberculosis bacilli still posing a threat. Polymorphism of genes regulating anti-mycobacterial properties of macrophages. Pol J Microbiol, 2006,55(1):7–12

    PubMed  Google Scholar 

  12. El Sahly HM, Reich RA, Dou SJ, et al. The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups. Scand J Infect Dis, 2004,36(2):106–108

    Article  PubMed  Google Scholar 

  13. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994,50(4):1088–1101

    Article  PubMed  CAS  Google Scholar 

  14. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997,315(7109):629–634

    Article  PubMed  CAS  Google Scholar 

  15. Feng FM, Wang D, Guo M, et al. A case control study on mannose-binding protein genetic polymorphism and susceptibility to pulmonary tuberculosis. Mod Prevent Med, 2007,34(3):438–440

    CAS  Google Scholar 

  16. Zhou J, Zhang WJ, Zhang J, et al. Correlation of polymorphism of mannan-binding lectin gene to tuberculosis. Progr Mod Biomed, 2010,10(18):3569–3573

    CAS  Google Scholar 

  17. Li Y, Zhang WJ. Progress in mannose-binding lectin and its genetic susceptibility to tuberculosis. Chin J Immun, 2010,26(10):948–952

    CAS  Google Scholar 

  18. Lian YY, Han M, Le J. Progress in tuberculosis susceptibility genes. Int J Lab Med, 2008,29(10):896–898

    CAS  Google Scholar 

  19. Guo YL, Liu Y, Song CX, et al. Progress in tuberculosis susceptibility genes. Tuber Thor Tumor, 2009,1:62–64

    Google Scholar 

  20. Liu ZB, Zheng RJ, Xiao HP, et al. The correlation between polymorphisms of genes with susceptibility to tuberculosis and the clinical characteristics of tuberculosis in 459 Han patients. Zhonghua Jie He He Hu Xi Za Zhi (Chinese), 2011,34(12):923–928

    Google Scholar 

  21. Liu YD, Zheng RJ, Xiao HP, et al. Study on the correlation between polymorphisms of genes with susceptibility to tuberculosis and drug-resistant tuberculosis in Chinese Han population. Zhonghua Liu Xing Bing Xue Za Zhi (Chinese), 2011,32(3):279–284

    CAS  Google Scholar 

  22. Feng FM, Liu Q, Guo M, et al. Relationship between mannose-binding protein P54 allele polymorphisms and susceptibility to pulmonary tuberculosis. Chin J Publ Health, 2006,22(11):1353–1355

    CAS  Google Scholar 

  23. Liu W, Zhang F, Zhao QM, et al. Sequence variations in the mannose binding lectin gene and their possible relationship in susceptibility to tuberculosis in the Chinese Han nationality. Chin Trop Med, 2006,6(3):387–389

    Google Scholar 

  24. Feng FM, Guo M, Liu Q, et al. Study on mannose-binding protein gene polymorphisms and susceptibility to pulmonary tuberculosis. Zhonghua Liu Xing Bing Xue Za Zhi (Chinese), 2006,27(12):1082–1085

    CAS  Google Scholar 

  25. Li Y, Pei XY, Zhang SY, et al. The usage of multifactor dimensionality reduction method in the research of tuberculosis susceptible gene-gene interactions. J Ningxia Med Univ (Chinese), 2011,33(2):138–139

    CAS  Google Scholar 

  26. Sun B, Cui XQ, Guo YF, et al. Association study of gene polymorphism of mannose binding lectin and pulmonary tuberculosis. Chongqing Med (Chinese), 2012,41(19):1917–1919

    CAS  Google Scholar 

  27. Zhang J, Deng XL, Wang X, et al. A study on the association of polymorphisms of the MBL gene with the susceptibility to tuberculosis of Xinjiang Hazakhs. J Nongken Med (Chinese), 2011,33(2):135–138

    Google Scholar 

  28. Liu W, Zhang F, Xin ZT, et al. Sequence variations in the MBL gene and their relationship to pulmonary tuberculosis in the Chinese Han population. Int J Tuberc Lung Dis, 2006,10(10):1098–1103

    PubMed  CAS  Google Scholar 

  29. Feng FM, Hao JQ, Chen Y, et al. Relationship of gene-gene interaction of VDR and MBP loci with susceptibility to pulmonary tuberculosis of Han population in Tangshan Hebei. Chongqing Med J (Chinese), 2010,39(12):1527–1529

    CAS  Google Scholar 

  30. Li Y, Wu F, Zhang L, et al. Association between polymorphism of MBL gene with susceptibility to tuberculosis in Han population in Xinjiang. Chin J Zoon (Chinese), 2011,27(9):769–773

    CAS  Google Scholar 

  31. Fang GX, Yin CL. Research on relationship of polymorphism of mannose-binding lectin gene with susceptibility to tuberculosis in Zhuang population. Int J Respir, 2011,31(6):428–430

    Google Scholar 

  32. Zhou J, Deng XL, Wang X, et al. Study on the correlation between MBL-H/L, P/Q polymorphisms with the susceptibility of TB in Xinjiang Uighurs population. Med Healthc Appar, 2011,18(7):976–978

    Google Scholar 

  33. Zhou J, Zhang WJ. Correlation between MBL-A/B gene with the susceptibility of tuberculosis in Xinjiang Uighur population. Chin J Antituberc (Chinese), 2012,34(7):445–451

    CAS  Google Scholar 

  34. Denholm JT, McBryde ES, Eisen DP. Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis. Clin Exp Immunol, 2010,162(1):84–90

    Article  PubMed  CAS  Google Scholar 

  35. Garred P, Larsen F, Madsen HO, et al. Mannose-binding lectin deficiency-revisited. Mol Immunol, 2003,40(2–4):73–84

    Article  PubMed  CAS  Google Scholar 

  36. Chatterjee D. The mycobacterial cell wall: structure, biosynthesis and sites of drug action. Curr Opin Chem Biol, 1997,1(4):579–588

    Article  PubMed  CAS  Google Scholar 

  37. Polotsky VY, Belisle JT, Mikusova K, et al. Interaction of human mannose-binding protein with Mycobacterium avium. J Infect Dis, 1997,175(5):1159–1168

    Article  PubMed  CAS  Google Scholar 

  38. Garred P, Larsen F, Seyfarth J, et al. Mannose-binding lectin and its genetic variants. Genes Immun, 2006,7(2):85–94

    Article  PubMed  CAS  Google Scholar 

  39. Dommett RM, Klein N, Turner MW. Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens, 2006,68(3):193–209

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Respiration and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Jing Shi  (施 静), Min Xie  (谢 敏), Jian-miao Wang  (王坚苗), Yong-jian Xu  (徐永健), Wei-ning Xiong  (熊维宁) & Xian-sheng Liu  (刘先胜)

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  1. Jing Shi  (施 静)
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  2. Min Xie  (谢 敏)
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  3. Jian-miao Wang  (王坚苗)
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  4. Yong-jian Xu  (徐永健)
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  6. Xian-sheng Liu  (刘先胜)
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Correspondence to Xian-sheng Liu  (刘先胜).

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Shi, J., Xie, M., Wang, Jm. et al. Mannose-binding lectin two gene polymorphisms and tuberculosis susceptibility in Chinese population: A meta-analysis. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 33, 166–171 (2013). https://doi.org/10.1007/s11596-013-1091-1

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  • DOI: https://doi.org/10.1007/s11596-013-1091-1

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