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Expression of IRF-4 and IBP in skin lesions of patients with psoriasis vulgaris

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Summary

The expression of the interferon regulatory factor 4 (IRF-4) and the IRF-4-binding protein (IBP) in psoriatic skin lesions was investigated. The expression of IRF-4 and IBP in skin lesions of 20 patients with psoriasis vulgaris were immunohistochemically dectected. Normal skin from 10 healthy people was used as normal control. The study showed that expression of IRF-4 was increased significantly in keratinocytes and inflammatory cells in the lesions of psoriasis vulgaris than that in the normal control. The detection revealed that IBP expression in keratinocytes, lymphocytes, hair follicles, and sebaceous glands in normal skin was significantly lower than that in the lesions of psoriasis vulgaris (P<0.05). Both IRF-4 and IBP might be involved in the pathogenesis of psoriasis vulgaris.

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Authors and Affiliations

  1. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Anhong Ni  (倪安红), Hongxiang Chen  (陈宏翔), Yan Wu  (吴 艳), Wen Li  (李 雯), Shanjuan Chen  (陈善娟) & Jiawen Li  (李家文)

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  1. Anhong Ni  (倪安红)
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  2. Hongxiang Chen  (陈宏翔)
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  3. Yan Wu  (吴 艳)
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  4. Wen Li  (李 雯)
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  5. Shanjuan Chen  (陈善娟)
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  6. Jiawen Li  (李家文)
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Corresponding author

Correspondence to Jiawen Li  (李家文).

Additional information

This project was supported by grants from the National Natural Sciences Foundation of China (No. 30972654 and No. 81171495).

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Ni, A., Chen, H., Wu, Y. et al. Expression of IRF-4 and IBP in skin lesions of patients with psoriasis vulgaris. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 32, 287–290 (2012). https://doi.org/10.1007/s11596-012-0050-6

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  • DOI: https://doi.org/10.1007/s11596-012-0050-6

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