Summary
This study prospectively examined the intranasal distribution of nasal spray after nasal septal correction and decongestant administration. A cohort of 20 patients was assessed for the distribution of nasal spray before and after nasal septum surgery. Sprays were dyed and administered one puff per nostril when patients hold their head up in an upright position. Before and after decongestant administration, the intranasal distribution was semi-quantitatively determined by nasal endoscopy. The results showed that the dyed drug was preferentially sprayed onto the nasal vestibule, the head of the inferior turbinate, the anterior part of septum and nasal floor. As far as the anterior-inferior segment of the nasal cavity was concerned, the distribution was found to be influenced neither by the decongestant nor by the surgery (P>0.05). However, both the decongestant and surgery expanded the distribution to the anatomical structures in the superior and posterior nasal cavity such as olfactory fissure, middle turbinate head and middle nasal meatus. No distribution was observed in the sphenoethmoidal recess, posterior septum, tail of inferior turbinate and nasopharynx. It was concluded that nasal septum surgery and decongestant administration significantly improves nasal spray distribution in the nasal cavity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Fokkens W, Lund V, Mullol J, et al. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl, 2007,45(20):1–136
Harvey RJ, Schlosser RJ. Local drug delivery. Otolaryngol Clin North Am, 2009,42(5):829–845
Merkus P, Ebbens FA, Muller B, et al. Influence of anatomy and head position on intranasal drug deposition. Eur Arch Otorhinolaryngol, 2006,263(9):827–832
Tsikoudas A, Barnes ML, White PS. The effect of functional endoscopic sinus surgery on nasal spray distribution to the middle meatus in patients with rhinosinusitis. Am J Rhinol Allergy, 2009,23(5):546–548
Benninger MS, Hadley JA, Osguthorpe JD, et al. Techniques of intranasal steroid use. Otolaryngol Head Neck Surg, 2004,130(1):5–24
Hardy JG, Lee SW, Wilson CG. Intranasal drug delivery by spray and drops. J Pharm Pharmacol, 1985,37(5):294–297
Scheibe M, Bethge C, Martin W, et al. Intranasal administration of drugs. Arch Otolaryngol Head Neck Surg, 2008,134(6):643–646
Sanan JD, Laube BL, Lin TC, et al. Validity of in vitro tests on aqueous spray pumps as urrogates for nasal deposition. Pharm Res, 2002,19(1):1–6
Timothy R. Harlan R, Gilbert E, et al. Comparison of topical medication delivery systems after sinus surgery. Laryngoscope, 2004,114(2):201–204
Proctor DF. Nasal mucous transport and our ambient air. Laryngoscope, 1983,93(1):58–62
Newman SP, Moren PF, Clarke SW. The nasal distribution of metered dose inhalers. J Laryngol Otol, 1987,101(2):127–132
Berridge MS, Heald DL, Muswick GJ, et al. Biodistri bution and kinetics of nasal carbon-11-triamcinolone acetonide. J Nucl Med, 1998, 39(11):1972–1977
Wormald PJ, Cain T, Oates L, et al. A comparative study of three methods of nasal irrigation. Laryngoscope, 2004,114(12):2224–2227
Author information
Authors and Affiliations
Corresponding authors
Additional information
This study was supported by a grant from National Natural Science Foundation of China (No. 81070772), and Zhuhai Medical Scientific Research Fund (No. PC20081046).
Rights and permissions
About this article
Cite this article
Mi, J., Fan, Y., Feng, S. et al. Septoplasty and decongestant improve distribution of nasal spray. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 837–841 (2011). https://doi.org/10.1007/s11596-011-0687-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11596-011-0687-6