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Effects of variant rs346473 in ARHGAP24 gene on disease progression of HBV infection in han Chinese population

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Summary

Host genetic, environmental and viral factors are classified as three categories that determine clinical outcomes of hepatitis B virus (HBV) infection. The objective of this study was to detect the associations between polymorphisms rs346473 and rs346482 in Rho GTPase-activating protein 24 (ARHGAP24) gene and disease progression of HBV infection in Han Chinese population. These two SNPs were found by our DNA pooling using Affymetrix Genome-Wide Human Mapping SNP6.0 Array in HBV carriers, and verified by using TaqMan 7900HT Sequence Detection System with 758 progressed HBV carriers versus 300 asymptomatic HBV carriers (AsC) in a discovery phase and 971 progressed HBV carriers versus 328 AsC in a replication phase. Multivariable logistic regression revealed that individuals with genotype TT at variant rs346473 displayed remarkable correlations with disease progression of HBV infection both in the discovery phase (OR, 2.693; 95% CI, 1.928–3.760; P=6.2×10−9; additive model) and the replication phase (OR, 1.490; 95% CI, 1.104–2.012; P=9.0×10−3; additive model). These two SNPs were in strong linkage disequilibrium with D′=0.99 and r 2=0.951, and haplotype TT disclosed an increased susceptibility to HBV progression (OR, 1.980; 95% CI, 1.538–2.545; P=8.1×10−8). These findings suggest that polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants underlying the susceptibility of HBV carriers to disease progression.

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Authors and Affiliations

  1. Institute of Liver Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Lifeng Liu  (刘丽凤), Jinjian Yao  (姚津剑), Jin Li  (里 进), Jinling Yu  (余金玲), Xiaorui Jiang  (姜小瑞), Shuzhen Sun  (孙淑珍), Qing Liu  (刘 庆), Ying Chang  (常 莹) & Jusheng Lin  (林菊生)

  2. Liaocheng People’s Hospital, Liaocheng, 252000, China

    Lifeng Liu  (刘丽凤) & Jinliang Zhang  (张金良)

  3. Department of Infection Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Yongwen He  (贺永文)

Authors
  1. Lifeng Liu  (刘丽凤)
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  2. Jinjian Yao  (姚津剑)
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  3. Jin Li  (里 进)
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  4. Jinliang Zhang  (张金良)
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  5. Jinling Yu  (余金玲)
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  6. Xiaorui Jiang  (姜小瑞)
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  7. Shuzhen Sun  (孙淑珍)
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  8. Qing Liu  (刘 庆)
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  9. Ying Chang  (常 莹)
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  10. Yongwen He  (贺永文)
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  11. Jusheng Lin  (林菊生)
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Corresponding author

Correspondence to Jusheng Lin  (林菊生).

Additional information

This manuscript was supported by the national basic research program of China (Grant number: No. 2007CB512900) and the national natural science foundation of China (Grant number: No. 30872237).

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Liu, L., Yao, J., Li, J. et al. Effects of variant rs346473 in ARHGAP24 gene on disease progression of HBV infection in han Chinese population. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 482–487 (2011). https://doi.org/10.1007/s11596-011-0477-1

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  • DOI: https://doi.org/10.1007/s11596-011-0477-1

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