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Effects of SNPs at newly identified lipids loci on blood lipid levels and risk of coronary heart disease in Chinese Han population: A case control study

Journal of Huazhong University of Science and Technology [Medical Sciences] volume 31, Article number: 452 (2011) Cite this article

Summary

Associations between “lipid-related” candidate genes, blood lipid concentrations and coronary artery disease (CHD) risk are not clear. We aimed to investigate the effect of three newly identified lipids loci from genome-wide association studies on CHD and blood lipid levels in Chinese Han population. The genotypes of SNPs at three newly identified lipid loci and blood lipids concentrations were examined in 1360 CHD patients and 1360 age- and sex-frequency matched controls from an unrelated Chinese Han population. Allele T of rs16996148 occurred less frequently in CHD patients with the odds ratio (OR) being 0.64 (95% CI 0.50 to 0.81), after adjusting for conventional risk factors and was associated with a 33% decreased CHD risk (P<0.01) comparing with the major allele G. Individuals with GT genotype had the lowest CHD risk. No associations were found between the polymorphisms of other two loci with CHD risk and all three SNPs had no effect on lipid profile in this population. SNP rs16996148 on chromosome 19p13 is significantly associated with lower risk for CHD in Chinese Han population. However, it remains unresolved why these lipid-related loci had significantly less effects than the correspondingly expected effects on blood lipids levels in this population.

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Affiliations

  1. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Ke Zhuang, Wencai Zhang, Xiaobo Zhang, Fangqin Wu & Longxian Cheng

Authors
  1. Ke Zhuang
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  2. Wencai Zhang
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  3. Xiaobo Zhang
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  4. Fangqin Wu
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  5. Longxian Cheng
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Corresponding author

Correspondence to Longxian Cheng.

Additional information

This project was supported by grants from the National Natural Sciences Foundation of China (No. 30525031 and No. 30430590).

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Zhuang, K., Zhang, W., Zhang, X. et al. Effects of SNPs at newly identified lipids loci on blood lipid levels and risk of coronary heart disease in Chinese Han population: A case control study. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 452 (2011). https://doi.org/10.1007/s11596-011-0472-6

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  • DOI: https://doi.org/10.1007/s11596-011-0472-6

Key words

  • coronary heart disease
  • blood lipids
  • lipid loci
  • single nucleotide polymorphism
  • Chinese Han population