Summary
This study examined the clinical features of complications of congenital retinoschisis and the clinical efficacy of vitreoretinal surgery in the treatment of these complications. The clinical efficacy of surgical treatments was retrospectively analyzed in 10 patients with congenital retinoschisis (10 eyes) complicated with rhegmatogenous retinal detachment (n=5), vitreous hemorrhage (n=2) and macula- involving schisis (n=1). All the patients suffered foveal and peripheral schisis. They were treated with scleral buckling (n=1) or vitrectomy (n=9). After the surgical treatment, the retina was reattached in patients with rhegmatogenous retinal detachment; the refractive media became transparent in those with vitreous hemorrhage; the visual acuity in 80% of patients was improved; no remarkable progression of schisis was found; no severe operative complications occurred. It was concluded that vitreoretinal surgery in the treatment of complications of congenital retinoschisis is safe and effective, and helps improve and maintain the visual function.
Similar content being viewed by others
References
Kjellström S, Vijayasarathy C, Ponjavic V, et al. Long- term 12 year follow-up of X-linked congenital retinoschisis. Ophthalmic Genet, 2010,31(3):113–125
Hamaguchi H, Wada I, Takigawa J, et al. A case of congenital retinoschisis in a 34-week gestation female infant. Nippon Ganka Gakkai Zasshi, 1989,93(5):575–580
Kellner U, Brümmer S, Foerster MH, et al. X-chrom- osomal congenital retinoschisis. Clinical aspects and electrophysiology. Fortschr Ophthalmol, 1990,87(3): 264–268
Kłosowska-Zawadka A, Bernardczyk-Meller J, Gotz-Wieckowska A, et al. Importance of family examination in juvenile X-linked retinoschisis. Ophthalmologe, 2005,102(12):1193–1199
Lisch W. Follow-up study of X-linked retinoschisis. Graefes Arch Clin Exp Ophthalmol, 1991,229(5):497
Renner AB, Kellner U, Fiebig B, et al. ERG variability in X-linked congenital retinoschisis patients with mutations in the RS1 gene and the diagnostic importance of fundus autofluorescence and OCT. Doc Ophthalmol, 2008,116(2): 97–109
Renner AB, Kellner U, Cropp E, et al. Dysfunction of transmission in the inner retina: incidence and clinical causes of negative electroretinogram. Graefes Arch Clin Exp Ophthalmol, 2006,11:1467–1473
Miyake Y, Shiroyama N, Ota I, et al. Focal macular electroretinogram in X-linked congenital retinoschisis. Invest Ophthalmol Vis Sci, 1993,34(3):512–515
Koh AH, Hogg CR, Holder GE. et al. The incidence of negative ERG in clinical practice. Doc Ophthalmol, 2001,102(1):19–30
Pojda-Wilczek D. Electroretinogram and electrooculogram in retinal degeneration. Klin Oczna, 1999,101(6): 481–485
Kellner U, Foerster MH. AC and DC electroretinography in degenerative retinal diseases. Fortschr Ophthalmol, 1990,87(2):196–200
Dhingra S, Patel CK. Diagnosis and pathogenesis of congenital X-linked retinoschisis with optical coherence tomography. J Pediatr Ophthalmol Strabismus, 2010,47(2):105–107
Prenner JL, Capone A Jr, Ciaccia S, et al. Congenital X-linked retinoschisis classification system. Retina, 2006,26(7 Suppl):S61–66
Jiang CH, Wang WJ, Wang L, et al. Optic coherence tomography study of macular retioschisis. Chin Ophthalmic Res (Chinese), 2008,26(6):333–335
Mosin IM, Moshetova LK, Mishustin VV, et al. Bullous form of X-linked congenital retinoschisis in infants. Vestn Oftalmol, 2001,117(1):30–33
Kageyama M, Nakatsuka K, Miyake Y. A case of congenital retinoschisis with unexpected appearance and spontaneous regression. Nippon Ganka Gakkai Zasshi, 1997,101(8):698–702
Turut P, François P, Castier P, et al. Analysis of results in the treatment of peripheral retinoschisis in sex-linked congenital retinoschisis. Graefes Arch Clin Exp Ophthalmol, 1989,227(4):328–331
Kellner U, Brummer S, Foerster MH, et al. X-linked congenital retinoschisis. Graefes Arch Clin Exp Ophthalmol, 1990,228(5):432–437
Gopal L, Shanmugam MP, Battu RR, et al. Congenital retinoschisis: successful collapse with photocoagulation. Indian J Ophthalmol, 2001,49(4):265–266
Wu WC, Drenser KA, Capone A, et al. Plasmin enzyme-assisted vitreoretinal surgery in congenital X-linked retinoschisis: surgical techniques based on a new classification system. Retina, 2007,27(8):1079–1085
Ferrone PJ, Trese MT, Lewis H. Vitreoretinal surgery for complications of congenital retinoschisis. Am J Ophthalmol, 1997,123(6):742–747
García-Arumí J, Corcóstegui IA, Navarro R, et al. Vitreoretinal surgery without schisis cavity excision for the management of juvenile X linked retinoschisis. Br J Ophthalmol, 2008,92(11):1558–1560
Joshi MM, Drenser K, Hartzer M, et al. Intraschisis cavity fluid composition in congenital X-linked retinoschisis. Retina, 2006,26(7 Suppl):S57–60
Li JQ, Tang SB, Zhu XB, et al. Vitreoretinal surgery for congenital retinoschisis. Chin J Ocular Fundus Diseases (Chinese), 2005,21(2):127–128
Jia ZY, Zhao PQ, Li Q, et al. Vitreoretinal surgery for posterior segment complications of congenital retinoschisis. Chin J Ocular Trauma Occupational Eye Disease (Chinese), 2006,28(1):19–21
Pradhan M, Hayes I, Vincent A. An audit of genetic testing in diagnosis of inherited retinal disorders: a prerequisite for gene-specific intervention. Clin Experiment Ophthalmol, 2009,37(7):703–711
Goodwin P. Hereditary retinal disease. Curr Opin Ophthalmol, 2008,19(3):255–262
Liu MM, Tuo J, Chan CC. Gene therapy for ocular diseases. Br J Ophthalmol, 2011,95(5):604–612
Shastry BS, Hejtmancik FJ, Trese MT. Recurrent missense (R197C) and nonsense (Y89X) mutations in the XLRS1 gene in families with X-linked retinoschisis. Biochem Biophys Res Commun, 1999,256(2):317–319
Falcone PM, Brockhurst RJ. X-chromosome-linked juvenile retinoschisis: clinical aspects and genetics. Int Ophthalmol Clin, 1993,33(2):193–202
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
You, J. Surgical treatment for complications of congenital retinoschisis. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 404–408 (2011). https://doi.org/10.1007/s11596-011-0390-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11596-011-0390-7