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Lack of association of common polymorphism of LRP1 gene with myocardial infarction in a Chinese Han population

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Summary

This study examined the association of a common polymorphic allele (25G) of the low-density lipoprotein receptor-related protein1 (LRP1) gene with myocardial infarction (MI). The genotypes of LRP1 25CG (rs35282763) were determined in 347 MI patients and 347 age- and sex-frequency-matched controls from an unrelated Chinese Han population. Factor VIII (FVIII) levels were measured in the MI patients and controls by chromogenic assay and enzyme-linked immunosorbent assay (ELISA). The results showed that LRP1 25CG (rs35282763) genotype distribution did not differ significantly between patients (n=206 for 25CC, n=122 for 25CG) and controls (n=191 for 25CC, n=126 for 25CG; P>0.05). The 25G allele was not associated with a reduced risk of MI (P>0.05). Further stratifications for age, sex, and other cardiovascular risk factors did not affect the negative findings. It was concluded that the presence of the G allele at the 25CG (rs35282763) polymorphism of the LRP1 is not associated with a reduced risk of MI, and genotyping for LRP1 25CG (rs35282763) polymorphism is not useful in assessing the individual risk of MI.

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Authors and Affiliations

  1. Institute of Hematology and the Ministry of Education Key Lab of Targeted Biotherapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Honggang Ren  (任红刚), Tao Guo  (郭 涛), Huafang Wang  (王华芳), Chunyan Sun  (孙春艳), Xiaoping Zhang  (张小平), Heng Mei  (梅 恒) & Yu Hu  (胡 豫)

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  1. Honggang Ren  (任红刚)
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  2. Tao Guo  (郭 涛)
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  3. Huafang Wang  (王华芳)
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  4. Chunyan Sun  (孙春艳)
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  5. Xiaoping Zhang  (张小平)
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  6. Heng Mei  (梅 恒)
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  7. Yu Hu  (胡 豫)
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Corresponding author

Correspondence to Yu Hu  (胡 豫).

Additional information

This work was supported by grants from the National Basic Scientific Research Program of China (973 Program, No. 2007CB935803) and the National Natural Sciences Foundation of China (No. 30825018).

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Ren, H., Guo, T., Wang, H. et al. Lack of association of common polymorphism of LRP1 gene with myocardial infarction in a Chinese Han population. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 295–300 (2011). https://doi.org/10.1007/s11596-011-0370-y

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  • DOI: https://doi.org/10.1007/s11596-011-0370-y

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