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Clinical effects of intensive insulin therapy treating traumatic shock combined with multiple organ dysfunction syndrome

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Summary

The therapeutic effects of intensive insulin therapy in treatment of traumatic shock combined with multiple organ dysfunction syndrome (MODS) were investigated. A total of 114 patients with traumatic shock combined with MODS were randomly divided into two groups: control group (n=56) treated with conventional therapy, and intensive insulin therapy group (n=58) treated with conventional therapy plus continuous insulin pumping to control the blood glucose level at range of 4.4–6.1 mmol/L. White blood cells (WBC) counts, prothrombin time (PT), serum creatinine (SCr), alanine aminotransferase (ALT), serum albumin and PaO2 were measured before and at the day 1, 3, 5, 7 and 14 after treatment. The incidence of gastrointestinal dysfunction, the incidence of MODS, hospital stay and the mortality were also observed and compared. After intensive insulin therapy, the WBC counts, SCr, ALT and PT were significantly reduced (P<0.05), but the level of serum albumin was significantly increased (P<0.05) at the day 3, 5, 7 and 14. In the meantime, the PaO2 was significantly elevated at the day 3, 5 and 7 (P<0.01) after intensive insulin therapy. The incidence of gastrointestinal dysfunction, the incidence of MODS, the length of hospital stay and the mortality were markedly decreased (P<0.01). The results suggest early treatment with intensive insulin therapy is effective for traumatic shock combined with MODS and can decrease the length of hospital stay and the mortality.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, First Affiliated Hospital to General Hospital of PLA, Beijing, 100037, China

    Jundong Du  (杜俊东), Rong Liu  (刘 荣), Yongming Yao  (姚咏明), Huabo Jiao  (焦华波), Xiaodong Zhao  (赵晓东), Huinan Yin  (尹会男) & Zhanliang Li  (黎沾良)

  2. Department of Hepatobiliary Surgery, Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042, China

    Hongming Liu  (刘宏鸣)

Authors
  1. Jundong Du  (杜俊东)
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  2. Hongming Liu  (刘宏鸣)
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  3. Rong Liu  (刘 荣)
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  4. Yongming Yao  (姚咏明)
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  5. Huabo Jiao  (焦华波)
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  6. Xiaodong Zhao  (赵晓东)
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  7. Huinan Yin  (尹会男)
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  8. Zhanliang Li  (黎沾良)
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Corresponding author

Correspondence to Rong Liu  (刘 荣).

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Both authors contributed equally to this work.

This project was supported by a grant from National Natural Sciences Foundation of China (No. 30870951).

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Du, J., Liu, H., Liu, R. et al. Clinical effects of intensive insulin therapy treating traumatic shock combined with multiple organ dysfunction syndrome. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 194–198 (2011). https://doi.org/10.1007/s11596-011-0251-4

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  • DOI: https://doi.org/10.1007/s11596-011-0251-4

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