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Relationship between plasma ghrelin levels and insulin resistance and blood pressure in octogenarians

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Summary

The association between fasting plasma ghrelin levels and insulin resistance and blood pressure (BP) in octogenarians was investigated in this study. A total of 487 unrelated octogenarians (including 203 men and 284 women) were enrolled in this cross-sectional study at the Healthy Care Center of Shanghai East Hospital, Tongji University, China, from October 2008 to April 2009. Plasma ghrelin was determined by using the enzyme linked immunosorbent assay (ELISA). Insulin sensitivity was assessed using the homeostasis model of assessment-insulin resistance (HOMA-IR). The age of the participants ranged from 80 to 89 years (mean=83.9±4.8 years) with a body mass index (BMI) of 25.3±4.9 kg/m2. Plasma ghrelin levels were 20.94±5.34 μg/L, being 20.89±5.53 μg/L in men and 21.38±3.73 μg/L in women respectively. Plasma ghrelin was not associated with systolic (P=0.981) or diastolic (P=0.724) BP, waist circumference (P=0.278), fasting insulin (P=0.246), fasting blood glucose (FBG) (P=0.693) and HOMA-IR (P=0.232). In the control cohort, no significant differences in plasma ghrelin were found between genders (P=0.489), and among subjects with hypertension (BP>140/90 mmHg) (P=0.284) and type 2 diabetes (P=0.776). In conclusion, fasting plasma ghrelin levels are not directly correlated with insulin resistance and BP among octogenarians.

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Authors and Affiliations

  1. Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China

    Yintao Zhao  (赵荫涛) & Daifu Zhang  (张代富)

  2. Department of Geratology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China

    Li Shao  (邵 莉), Lili Teng  (滕丽莉) & Hua Zhang  (张 华)

Authors
  1. Yintao Zhao  (赵荫涛)
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  2. Li Shao  (邵 莉)
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  3. Lili Teng  (滕丽莉)
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  4. Daifu Zhang  (张代富)
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  5. Hua Zhang  (张 华)
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Corresponding author

Correspondence to Hua Zhang  (张 华).

Additional information

The two authors contributed equally to the work.

This project was supported by grants from the National Natural Sciences Foundation of China (No. 30600294) and Shanghai Scientific and Technological Innovation Plan (No. 08411951300).

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Zhao, Y., Shao, L., Teng, L. et al. Relationship between plasma ghrelin levels and insulin resistance and blood pressure in octogenarians. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 30, 307–311 (2010). https://doi.org/10.1007/s11596-010-0347-2

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  • DOI: https://doi.org/10.1007/s11596-010-0347-2

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