Summary
In this study, a novel polyurethane membrane, modified by superfine silk-fibroin powder, was prepared for small-diameter vascular grafting. Scanning electron microscopy, transmission electron microscopy, and histological examination were applied to evaluate histocompatibility of this polyurethane membrane. The polyurethane membrane was compared with polytetrafluoroethylene material. A pseudomembrane and gap formed between polytetrafluoroethylene and the surrounding tissues, and no cells infiltrated or grew into the polytetrafluoroethylene material. On the contrary, superfine silk-fibroin powder/polyurethane blend membrane merged tightly with the surrounding tissues without gaps, and cells infiltrated and grew into the material. Moreover, the negative effects of superfine silk-fibroin powder/polyurethane blend membrane on cells were less than those of its polytetrafluoroethylene counterpart. Our findings indicated that the superfine silk-fibroin powder/polyurethane blend membrane has better histocompatibility than polytetrafluoroethylene membrane. It is concluded that the superfine silk-fibroin powder/polyurethane blend membrane is a promising biomaterial for small-diameter prosthesis.
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This project was supported by a grant from the 973 Program of Ministry of Science and Technology of China (No. 2009CB526400).
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Ouyang, C., Xu, H., Wang, W. et al. In vivo histocompatibility evaluation of polyurethane membrane modified by superfine silk-fibroin powder. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 29, 508–511 (2009). https://doi.org/10.1007/s11596-009-0423-7
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DOI: https://doi.org/10.1007/s11596-009-0423-7