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The current state of pancreas-kidney transplantation in China: The indications, surgical techniques and outcome

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Summary

It is currently estimated that 50 million Chinese have diabetic mellitus (DM) with more than 90% of these being afflicted with type 2 DM. Concomitantly, the socio-economic improvements in China are supporting the adoption of pancreas-kidney transplantations as a treatment option for these patients. Recipient candidate pool has yet to be expanded and the final effect to be improved in clinical practice. To date, more than 250 pancreas-kidney transplants have been performed on patients with type 1 and type 2 DM. To improve the outcome, a new surgical technique that involves anastomosis of the graft duodenum to recipient jejunum side-to-side but not Roux-en-Y, has been devised for enteric drainage. Furthermore, the systemic venous drainage (SVD) has been used as the method of choice for endocrine secretions. Graft and recipient long-term survival in China was similar to that in America and Europe. Three-year survival rate of pancreas and kidney grafts was 92.2% and 90.2%, respectively, in our center. No difference in survival and graft function between type 1 and type 2 DM recipients was noted. It is concluded that pancreas-kidney transplantation is an effective way for the treatment of type 1 DM and some type 2 DM complicated with uremia.

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Authors and Affiliations

  1. Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430003, China

    Changsheng Ming  (明长生), Nianqiao Gong  (宫念樵) & Xiaoping Chen  (陈孝平)

Authors
  1. Changsheng Ming  (明长生)
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  2. Nianqiao Gong  (宫念樵)
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  3. Xiaoping Chen  (陈孝平)
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Corresponding author

Correspondence to Changsheng Ming  (明长生).

Additional information

The study was supported by grants from the Chinese Ministry of Public Health for Key Clinical Projects (No. 353 [2007]) and the Hepatic Surgery Clinical Research Centre of Hubei, China (2007).

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Ming, C., Gong, N. & Chen, X. The current state of pancreas-kidney transplantation in China: The indications, surgical techniques and outcome. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 29, 269–272 (2009). https://doi.org/10.1007/s11596-009-0301-3

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  • DOI: https://doi.org/10.1007/s11596-009-0301-3

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