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Tea polyphenols exerts anti-hepatitis B virus effects in a stably HBV-transfected cell line

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Summary

In this study, the anti-HBV effects of tea polyphenols (TP) were examined. After cells were exposed to TP for 3, 6, 9 days, amounts of HBsAg, HBeAg and HBV-DNA released into the supernatant of the cultured HepG2 2.2.15 cells were detected. TP, to some extent, inhibited the secretion of HBsAg and strongly suppressed the secretion of HBeAg in a dose-dependent (P<0.01) and time-dependent manner, with 50% maximal inhibitory concentration (IC50) value being 7.34 μg/mL on the 9th day, but the time-dependence was not significant (P=0.051). Expression of HBV-DNA in the supernatant of the cell culture also was significantly decreased in a dose-dependent fashion (P<0.01). The IC50 of TP in inhibiting HBV DNA was 2.54 μg/mL. It concluded that TP possessed potential anti-HBV effects and may be used as a treatment alternative for HBV infection.

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Authors and Affiliations

  1. Department of Hepatology and Infectious Diseases, Huazhong University of Science and Technology, Wuhan, 430022, China

    Pian Ye  (叶翩), Shuling Zhang  (张淑玲), Lei Zhao  (赵雷), Shenghua Jie  (揭盛华), Ran Pang  (庞然) & Shuli Li  (李淑莉)

  2. Central Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Jihua Dong  (董继华)

Authors
  1. Pian Ye  (叶翩)
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  2. Shuling Zhang  (张淑玲)
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  3. Lei Zhao  (赵雷)
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  4. Jihua Dong  (董继华)
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  5. Shenghua Jie  (揭盛华)
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  6. Ran Pang  (庞然)
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  7. Shuli Li  (李淑莉)
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Additional information

The project was supported by a grant from the R&D Department of Hubei Province (No. 2007B07).

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Ye, P., Zhang, S., Zhao, L. et al. Tea polyphenols exerts anti-hepatitis B virus effects in a stably HBV-transfected cell line. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 29, 169–172 (2009). https://doi.org/10.1007/s11596-009-0206-1

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  • DOI: https://doi.org/10.1007/s11596-009-0206-1

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