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Effect of excessive iodine on immune function of lymphocytes and intervention with selenium

Journal of Huazhong University of Science and Technology volume 27, pages 422–425 (2007)Cite this article

Summary

In order to study the effect of excessive iodine on immune function of lymphocytes and the role of selenium supplementation with excessive iodine intake, the changes of T lymphocyte number, ratio of subsets, activity of natural killer (NK) cells and lymphocytes proliferation response were investigated. 150 female BALB/C mice were randomly divided into 5 groups in terms of their body weight (n=30 in each group), and 10 of each group were taken as one batch for test. Mice in the 5 groups were orally administrated with iodine 0 (group I), 1500 (group II), 3000 (group III), 6000 μg/L (group IV), iodine 6000 μg/L plus selenium 0.3 mg/L (group V) respectively for 30 days Lymphocyte proliferation response, CD4+/CD8+, Th1/Th2 and the activity of NK cells were measured. CD4+/CD8+ was significantly lower, while lymphocyte proliferation response stronger, and Th1/Th2 and the activity of NK cells significantly higher in group IV than in group I (P<0.01). There was no significant difference in all indexes between group V and group I (P>0.05). It was suggested that excessive iodine as exogenous chemical materials can induce disorders of T lymphocyte immune function in mice. 0.3 mg/L selenium supplementation can protect mice against toxicity induced by 6000 μg/L iodine.

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Authors and Affiliations

  1. Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Chen Xiaoyi  (陈骁熠), Liu Liegang  (刘烈刚), Yao Ping  (姚 平), Yu Dong  (于 东), Hao Liping  (郝丽萍) & Sun Xiufa  (孙秀发)

  2. Department of Preventive Medicine, Guangzhou Medical Collage, Guangzhou, 510182, China

    Chen Xiaoyi  (陈骁熠)

Authors
  1. Chen Xiaoyi  (陈骁熠)
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  2. Liu Liegang  (刘烈刚)
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  3. Yao Ping  (姚 平)
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  4. Yu Dong  (于 东)
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  5. Hao Liping  (郝丽萍)
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  6. Sun Xiufa  (孙秀发)
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Corresponding author

Correspondence to Sun Xiufa  (孙秀发).

Additional information

CHEN Xiaoyi, female, born in 1965, Associate Professor, M.D., Ph.D.

This project was supported by a grant from the National Natural Sciences Foundation of China (No. 30230330).

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Chen, X., Liu, L., Yao, P. et al. Effect of excessive iodine on immune function of lymphocytes and intervention with selenium. J. Huazhong Univ. Sc. Technol. 27, 422–425 (2007). https://doi.org/10.1007/s11596-007-0418-1

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  • DOI: https://doi.org/10.1007/s11596-007-0418-1

Key words

  • excessive iodine
  • lymphocyte
  • immune function
  • intervention