Summary
In order to evaluate the applied value of soluble intracellular adhesion molecule-1 (sICAM-1) in acute rejection (AR) following liver transplantation, the expression of sICAM-1 protein was sequentially detected by using ELISA in serum and bile of 43 patients receiving liver transplantation. In AR group, the expression levels of sICAM-1 protein were increased 3 days before and immediately on the establishment of AR diagnosis, and there was significant difference in the expression of bile between AR group and control group (P<0.01). After reversion of AR with hormone intensive therapy, there was significant difference in the sICAM-1 protein expression of serum and bile between AR group and control group. It was concluded that the sequential detection of sICAM-1 protein level in serum and bile was a reliable and noninvasive method for the early diagnosis of AR after liver transplantation and was valuable to observe the curative effects of anti-AR therapy.
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Yu, Y., Chen, Z. & Ye, Q. The role of sICAM-1 detection in the diagnosis of acute rejection following liver transplantation. J. Huazhong Univ. Sc. Technol. 26, 580–582 (2006). https://doi.org/10.1007/s11596-006-0526-3
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DOI: https://doi.org/10.1007/s11596-006-0526-3