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The Study of Nerve Conduit with Biocompatibility and Electrical Stimulation Effect

  • Organic Materials
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Abstract

Conductive polymers show great promise because of their electrical property based on bioelectricity in vivo. In order to search electro-activity materials which insure abduction of tissue, we synthesized conductive nerve conduits with poly-dl-lactic-acid (PDLLA) and tetra-aniline (TA). Preparation technology of TA was optimized, and the properties of the conduit were studied. RSC96 cell were used to investigate the toxicity and electrical stimulation effect. SD rats were used to assess biocompatibility in vivo. The results showed that the reaction ratio of 1:1, the reaction time of 2 h and the HCl concentration of 2 mol/L were the optimum conditions for synthesis of TA. The influence of TA content on the mechanical properties, hydrophilicity, conductivity and microstructure of the nerve conduit was evaluated. Cell and histocompatibility study showed PDLLA/TA possessed good biocompatibility. These results showed it had application values in tissue projects.

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Author information

Author notes

  1. GUO Xinglei and LIU Gang are co-first authors, and they contributed equally to the work

Authors and Affiliations

  1. Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China

    Xinglei Guo  (郭兴蕾), Haixing Xu  (徐海星), Yunxuan Yu, Changsheng Ke, Xiaofei Ming, Meng Zhao, Zhijun Huang & Peihu Xu  (许沛虎)

  2. Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, 430060, China

    Gang Liu  (刘刚)

  3. Wuhan Mafangshan Middle School, Wuhan, 430070, China

    Qundi He

  4. Wuhan Kanghua Century Pharmaceutical Company, Wuhan, 430070, China

    Xiaobin Wang

Authors
  1. Xinglei Guo  (郭兴蕾)
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  2. Gang Liu  (刘刚)
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  3. Qundi He
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  4. Haixing Xu  (徐海星)
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  6. Changsheng Ke
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  8. Meng Zhao
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  9. Xiaobin Wang
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  10. Zhijun Huang
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  11. Peihu Xu  (许沛虎)
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Corresponding authors

Correspondence to Haixing Xu  (徐海星) or Peihu Xu  (许沛虎).

Additional information

Funded by the National Natural Science Foundation of China (Nos.51473130 and 51572206), and the Wuhan Huanghe Excellence Plan and Entrepreneurship Training Program of Wuhan University of Technology (Nos.20181049715010 and 20181049715018)

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Guo, X., Liu, G., He, Q. et al. The Study of Nerve Conduit with Biocompatibility and Electrical Stimulation Effect. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 33, 1530–1539 (2018). https://doi.org/10.1007/s11595-018-2002-x

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  • DOI: https://doi.org/10.1007/s11595-018-2002-x

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