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Structural and regulating characteristics of adjustable annulus-clearance nozzle used in supercritical fluid precipitation

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Abstract

A new type of adjustable nozzle with an annulus clearance between the surfaces of a revolved solid and the matched hole was analyzed, which contained matching parts, regulating parts, guiding elements, and sealing part. The general regulating function of the adjustable nozzle was derived and the regulating and matching characteristics were also analyzed. Through the analysis, it was concluded that the matching-profile curve of either the revolved body or matched hole should be chosen as a straight line in order to keep the linear regulating feature. Moreover, the multi-annulus-clearance nozzle was designed, and some experiments were carried out on preparing budesonide particles with the nozzle. According to the experimental results, it was proved that the annulus nozzles is practical in preparing micro-particles by supercritical fluid precipitation method.

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Authors and Affiliations

  1. School of Mechanical Engineering, Shandong University, Jinan, 250061, China

    Yanpeng Qu  (曲延鹏), Yan Liu  (刘燕) & Weiqiang Wang

  2. Shanda-Lunan Research Institute of Supercritical Fluid Technology, Jinan, 250061, China

    Yanpeng Qu  (曲延鹏), Weiqiang Wang & Aiju Li

  3. YuYao Entry-Exit Inspection and Quarantine Bureau of PRC, Yuyao, 315400, China

    Songming Liu

  4. School of Material Engineering, Shandong University, Jinan, 250061, China

    Aiju Li

Authors
  1. Yanpeng Qu  (曲延鹏)
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  2. Yan Liu  (刘燕)
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  3. Songming Liu
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  4. Weiqiang Wang
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  5. Aiju Li
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Corresponding author

Correspondence to Yan Liu  (刘燕).

Additional information

Funded by the Science and Technology Development Plan of Shandong Province (No.2014GGX108001)

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Qu, Y., Liu, Y., Liu, S. et al. Structural and regulating characteristics of adjustable annulus-clearance nozzle used in supercritical fluid precipitation. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 32, 1487–1492 (2017). https://doi.org/10.1007/s11595-017-1773-9

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  • DOI: https://doi.org/10.1007/s11595-017-1773-9

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