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Synthesis and bio-activities of poly (3,4-ethylenedioxythiophene) (PEDOT)/poly (styrene sulfonate) (PSS)/gelatin layer on indium tin oxide (ITO)-coated glass

  • Biomaterials
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Abstract

Poly (3, 4-ethylenedioxythiophene) (PEDOT), together with its dopes, such as poly (styrene sulfonate) (PSS), has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin can be polymerized into PEDOT/PSS polymers on indium tin oxide (ITO)-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass significantly decreases electrochemical impedance spectroscopy (EIS) and increases charge delivery capacity relative to the gelatin layer and bare ITO-coated glass, comparable to the PEDOT/PSS layer on ITO-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass enhances pheochromocytoma (PC 12) cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into the PEDOT/PSS polymers through electrochemical polymerization and the PEDOT/PSS/gelatin layer on ITO-coated glass possesses high electrochemical and biological activities.

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Authors and Affiliations

  1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China

    Li Sui  (随力), Binbin Peng, Sijia Huang, Yan Wang & Lihua Ju

Authors
  1. Li Sui  (随力)
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  2. Binbin Peng
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  3. Sijia Huang
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  4. Yan Wang
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  5. Lihua Ju
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Correspondence to Li Sui  (随力).

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Funded by National Natural Science Foundation of China (Nos.11179015, 51173108) and Innovation Program of Shanghai Municipal Education Commission (No.12ZZ143)

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Sui, L., Peng, B., Huang, S. et al. Synthesis and bio-activities of poly (3,4-ethylenedioxythiophene) (PEDOT)/poly (styrene sulfonate) (PSS)/gelatin layer on indium tin oxide (ITO)-coated glass. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 31, 662–670 (2016). https://doi.org/10.1007/s11595-016-1426-4

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  • DOI: https://doi.org/10.1007/s11595-016-1426-4

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