Skip to main content
SpringerLink
Log in

Preparation and characterization of the system SiO2-CaO-P2O5 bioactive glasses by microemulsion approach

  • Biomaterial
  • Published:
Journal of Wuhan University of Technology-Mater. Sci. Ed. Aims and scope Submit manuscript

Abstract

The system of SiO2-CaO-P2O5 bioactive glasses (BG) were successfully synthesized by microemulsion approach. X-ray diffraction (XRD),scanning electron micro scopy(SEM) and energy dispersive X-ray (EDX) analyses, transmission electron microscopy(TEM),Fourier transform infrared spectroscopy (FTIR), BET N2 gas adsorption analysis techniques were utilized in order to evaluate the phase composition, dimension, morphology, interconnectivity of pores and particle size of the synthesized BG respectiveely. The biocompatibility of BG was assessed by using dimethylthiazol diphenyl tetrazolium bromide (MTT).The BG scaffolds were implanted in rabbit mandibles and studied histologically. The results showed that the BG with a particle size less than 100 nm was prepared successfully. The measured BET specific surface area and pore volume was 113.9 m2/g and 0.28 cm3/g respectively. Cell cultures revealed that BG has been shown to have good biocompatibility and is also beneficial to the survival of Schwann cells, which can promote cell proliferation in vivo assay indicating that the BG can promote osteoconductivity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L L Hench, J Wilson. Clinical Perfomance of Skeletal Prostheses[M]. London: Chapman and Hall, 1995

    Google Scholar 

  2. Leonardi E, Ciapetti G, Baldini N, et al. Response of Human Bone Marrow Stromal Cells to a Resorbable P2O5-SiO2-CaO-MgO-Na2OK2O Phosphate Glass Ceramic for Tissue Engineering Application[J]. Acta Biomater., 2010,6:598–606

    Article  CAS  Google Scholar 

  3. M Navarro, M P Ginebra, J A Planell. Cellular Response to Calcium Phosphate Glasses with Controlled Solubility[J]. J.Biomed. Mater. Res., 2003,67:1 009–1 012

    Google Scholar 

  4. J M Polak, L L Hench, P Kemp. Future Strategies for Tissue and Organ Replacement[M]. London: Imperial College Press, 2002

    Google Scholar 

  5. Sepulveda, P Jones, J R Hench. Bioactive Sol-Gel Foams for Tissue Repair[J]. J. Biomed. Mater. Res., 2002,59:40–348

    Article  Google Scholar 

  6. M Khorami. InVitro Bioactivity and Biocompatibility of Lithium Substituted 45S5 Bioglass[J].Materials Science and Engineering, 2011, 31(7): 1 584–1 592

    CAS  Google Scholar 

  7. Hench, L L Wilson. An Introduction to Bioceramic[M]. Singapore: World Scientific, 1993

    Google Scholar 

  8. Gallardo, J Galliano, P Duran. Bioactive and Protective Sol-Gel Coatings on Metal for Orthopaedic Prostheses[J]. J.Sol-Gel Sci. Technol., 2001, 21(1): 65–74

    Article  CAS  Google Scholar 

  9. Pileni M P. The Role of Soft Colloidal Templates in Controlling the Size and Shape of Inorganic Nanocrystals[J]. Nat. Mater., 2003, 2:145–148

    Article  CAS  Google Scholar 

  10. Sun Y, Guo G, Tao D, et al. Reverse Microemulsion-Directed Synthesis of Hydroxyapatite Nanoparticles under Hydrothermal Conditions[J]. J. Phys. Chem. Solids, 2007, 68: 373–375

    Article  CAS  Google Scholar 

  11. Singh S, Bhardwaj P, Singh V, et al. Synthesis of Nanocrysta-lline Calcium Phosphate in Microemulsion-Effect of Nature of Surfactants[J]. J. Colloid. Interf. Sci., 2008, 9: 319–322

    Google Scholar 

  12. Lim G K, Wang J, Ng S C, et al. Processing of Fine Hydroxyapatite Powders via an Inverse Microemulsion Route[J].Mater. Lett., 1996, 28: 431–435

    Article  CAS  Google Scholar 

  13. Karagiozov C, Momchilova D. Synthesis of Nano-Sized Particles from Metal Carbonates by the Method of Reversed Micelles[J]. Chem. Eng. Process., 2005, 44(1):15–18

    Google Scholar 

  14. Arriagada F J. Synthesis of Nanosize Silica in a Nonionic Water-in-Oil Microemulsion[J]. J. Colloid Interf. Sci., 1999,211(2):210–214

    Article  CAS  Google Scholar 

  15. Paul B K, Moulik S P. Microemulsions:an Overview[J]. J. Disper. Sci. Technol., 1997;18(4): 301–304

    Article  CAS  Google Scholar 

  16. Kambara, K Shimura, N Ogawa M. Larger Scale Syntheses of Surfactant-Templated Nanoporous Silica Spherical Particles by the Stöber Method[J]. J.Ceram. Soc.Jpn., 2007, 115: 315–318

    Article  CAS  Google Scholar 

  17. Shimura N, Ogawa M. Preparation of Surfactant Templated Nanoporous Silica Spherical Particles by the Stöber Method. Effect of Solvent Composition on the Particle Size[J]. J. Mater. Sci., 2007, 42; 5 299–5 302

    Article  CAS  Google Scholar 

  18. M Mami, A Lucas-Girot, H Oudadesse, et al. Investigation of the Surface Reactivity of a Sol-Gel Derived Glass in the Ternary System SiO2-CaO-P2O5 [J]. Appl.Surf.Sci., 2008, 254: 7 386–7 393

    Article  CAS  Google Scholar 

  19. H S Yun. Effect of the Pore Structure of Bioactive Glass Balls on Biocompatibility in Vitro and in Vivo[J]. Acta Biomaterialia, 2011, 7; 2 651–2 660

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan, 430070, China

    Hongxin Wang  (王洪新), Xiaoming Chen & Youfa Wang

  2. Department of Mechanical and Electronic Engineering, West Anhui University, Liu’an, 237012, China

    Dongji Cheng

Authors
  1. Hongxin Wang  (王洪新)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaoming Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Youfa Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dongji Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hongxin Wang  (王洪新).

Additional information

Funded by Guangdong Science and Technology Tackling Project (No. 2010B031100002) and the Orientation of Lu’an Commissioned the West Anhui University Municipal Research Project (No. 2011LW009)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, H., Chen, X., Wang, Y. et al. Preparation and characterization of the system SiO2-CaO-P2O5 bioactive glasses by microemulsion approach. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 28, 1053–1057 (2013). https://doi.org/10.1007/s11595-013-0818-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11595-013-0818-y

Key words

Search

Navigation