Skip to main content
SpringerLink
Log in

Preparation and characterization of hydroxyapatite/γ-Fe2O3 hybrid nanostructure

  • Advanced materials
  • Published:
Journal of Wuhan University of Technology-Mater. Sci. Ed. Aims and scope Submit manuscript

Abstract

The hybrid particles composed of hydroxyapatite (HAp) and ferrite (γ-Fe2O3) were synthesized by two-step precipitation method. The effect of reaction temperature on the morphology of the hybrids was also studied. The resultant hybrids were characterized by transmission electron microscopy (TEM) and X-ray diffraction analysis(XRD). It was found that γ-Fe2O3 nanoparticles dispersed within the HAp matrix and these hybrids had a feather-like or spherical morphology when synthesized at 90 °C or room temperature, respectively. The magnetic properties of the hybrid showed good superparamagnetic feature, and they could be controlled by the external magnetic field.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dorozhkin SV. Calcium Orthophosphate Based Biocomposites and Hybrid Biomaterials[J]. J. Mater. Sci., 2009, 44: 2 343–2 387

    Article  CAS  Google Scholar 

  2. Uota M, Arakawa H, Kitamura N, et al. Synthesis of High Surface Area Hydroxyapatite Nanoparticles by Mixed Surfactant-mediated Approach[J]. Langmuir, 2005, 21: 4 724–4 728

    Article  CAS  Google Scholar 

  3. Jevtic M, Mitric M, Skapin SB. et al. Crystal Structure of Hydroxyapatite Nanorods Synthesized by Sonochemical Homogeneous Precipitation [J]. Crystal Growth & Design, 2008, 8: 2 217–2 222

    Article  CAS  Google Scholar 

  4. Matsumoto T, Okazaki M, Inoue M, et al. Hydroxyapatite Particles as A Controlled Release Carrier of Protein[J]. Biomaterials, 2004, 25: 3 807–3 812

    Article  CAS  Google Scholar 

  5. Mizushima Y, Ikoma T, Tanaka J, et al. Injectalbe Porous Hydroxyapatite Microparticles as A New Carrier for Protein and Lipophilic Drugs[J]. J. Control. Release, 2006, 110: 260–265

    Article  CAS  Google Scholar 

  6. Kumta PN, Sfeir C, Lee DH, et al. Nanostructured Calcium Phosphates for Biomedical Applications: Novel Synthesis and Characterization[J]. Acta Biomater., 2005, 1: 65–83

    Article  Google Scholar 

  7. Motskin M, Wright DM, Muller K, et al. Hydroxyapatite Nano and Microparticles: Correlation of Particle Properties with Cytotoxicity and Biostability [J]. Biomaterials, 2009, 30: 3 307–3 317

    Article  CAS  Google Scholar 

  8. Liu YC, Zhong H, Li LF, et al. Temperature Dependence of Magnetic Property and Photocatalytic Activity of Fe3O4/Hydroxyapatite Nanoparticles[J]. Materials Research Bulletin, 2010, 45: 2 036–2 039

    CAS  Google Scholar 

  9. Yang PP, Quan ZW, Li CX, et al. Bioactive, Luminescent and Mesoporous Europium-doped Hydroxyapatite as Drug Carrier[J]. Biomaterials, 2008, 29: 4 341–4 347

    CAS  Google Scholar 

  10. Mornet S, Vasseur S, Grasnet F, et al. Magnetic Nanoparticle Design for Medical Diagnosis Therapy[J]. J. Mater. Chem., 2004, 14: 2 161–2 175

    Article  CAS  Google Scholar 

  11. Chang Q, Zhu LH, Yu C, et al. Synthesis and Properties of Magnetic and Luminescent Fe3O4/SiO2/Dye/SiO2 Nanoparticles[J]. Journal of Luminescence, 2008, 128: 1 890–1 895

    Article  CAS  Google Scholar 

  12. Hou CH, Hou SM, Hsueh YS, et al. The in vivo Performance of Biomagnetic Hydroxyapatite Nanoparticles in Cancer Hyperthermia Therapy[J]. Biomaterials, 2009, 30: 3 956–3 960

    CAS  Google Scholar 

  13. Lu J, Jiao XL, Chen DR, et al. Solvothermal Synthesis and Characterization of Fe3O4 and γ-Fe2O3[J]. J. Phys. Chem. C, 2009, 113:4 012–4 017

    CAS  Google Scholar 

  14. Cao SW, Zhu YJ. Surfactant-free Preparation and Drug Release Property of Magnetic Hollow Core/shell Hierarchical Nanostructures [J]. J. Phys. Chem. C, 2008, 112: 12 149–12 156

    CAS  Google Scholar 

  15. Liu ZY, Yi GS, Zhang HT, et al. Monodisperse Silica Nanoparticles Encapsulating Upconversion Fluorescent and Superparamagnetic Nanocrystals [J]. Chem. Commun., 2008, 694: 694–696

    Article  Google Scholar 

  16. Yi DK, Selvan ST, Lee SS, et al. Silica-coated Nanocomposites of Magnetic Nanoparticles and Quantum Dots [J]. J. Am. Chem. Soc., 2005, 127: 4 990–4 991

    CAS  Google Scholar 

  17. Tran N, T. Webster J. Gene Expression and Nanoparticle Uptake by Osteoblasts Exposed to Hydroxyapatite Coated Superparamagnetic Nanoparticles[J]. Acta Biomaterialia, 2011, 7: 1 298–1 306

    Article  CAS  Google Scholar 

  18. Wakiya N, Yamasai M, Adachi T, et al. Preparation of Hydroxyapatiteferrite Composite Particles by Ultrasonic Spray Pyrolysis[J]. Materials Science and Engineering B, 2010, 173: 195–198

    Article  CAS  Google Scholar 

  19. Zhang Y, Li Z, Sun W, et al. A Magnetically Recyclable Heterogeneous Catalyst: Cobalt Nano-oxide Supported on Hydroxyapatite -encapsulated γ-Fe2O3 Nanocrystallites for Highly Efficient Olefin Oxidation with H2O2 [J]. Catalysis Communications, 2008, 10: 237–242

    Article  CAS  Google Scholar 

  20. Mamani L, Sheykhan M, Heydari A, et al. Sulfonic acid Supported on Hydroxyapatite-encapsulated γ-Fe2O3 Nanocrystallites as a Magnetically Bronsted Acid for N-formylation of Amines[J]. Applied Catalysis A:General, 2010, 377: 64–69

    Article  CAS  Google Scholar 

  21. Cai YR, Pan HH, Xu XR, et al. Ultrasonic Controlled Morphology Transformation of Hollow Calcium Phosphate Nanosphers: A Smart Biocompatible Drug Release System[J]. Chem. Mater., 2007, 19: 3 081–3 083

    Article  CAS  Google Scholar 

  22. Mori K, Kanai S, Hara T, et al. Development of Ruthenium-Hydroxyapatite-encapsulated Superparamagnetic γ-Fe2O3 Nanocrystallites and an Efficient Oxidation Catalyst by Molecular Oxygen[J]. Chem. Mater., 2007, 19: 1 249–1 256

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China

    Ruixue Sun  (孙瑞雪), Kezheng Chen  (陈克正) & Lei Xu

Authors
  1. Ruixue Sun  (孙瑞雪)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kezheng Chen  (陈克正)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lei Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kezheng Chen  (陈克正).

Additional information

Funded by the Project of Shandong Province Higher Educational Science and Technology Program (No. J09LC13) and the Promotive Research Fund for Excellent Young and Middle-Aged Scientists of the Shandong Province (No. BS2010CL018)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sun, R., Chen, K. & Xu, L. Preparation and characterization of hydroxyapatite/γ-Fe2O3 hybrid nanostructure. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 28, 215–219 (2013). https://doi.org/10.1007/s11595-013-0667-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11595-013-0667-8

Key words

Search

Navigation