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Chitosan and β-cyclodextrin microspheres as pulmonary sustained delivery systems

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Abstract

Chitosan and β-cyclodextrin were used to prepare microspheres with theophylline for pulmonary delivery by spray drying method. The characteristics, mucociliotoxicity, permeation rate and drug release were studied. The drug entrapments of microspheres I, II and III were from 35.70% to 21.09% and 13.33%, while yields and encapsulation efficiencies were higher than 45% and about 90% respectively. The microspheres possessed low tap densities (0.34–0.48 g/cm3), appropriate diameters (3.35–3.94 μm) and theoretical aerodynamics diameters (2.20–3.04 μm). SEM images showed the microspheres were spherical with smooth or wrinkled surface surfaces. FT-IR demonstrated theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin. The microspheres could effectively reduce the ciliotoxicity and easy to penetrate the memberine. The in vitro release of the microspheres was related to the ratio of drug/polymer and microspheres II had a prolong release, providing the release of 72.00% in 12 h. The results suggestes that chitosan/β-cyclodextrin microspheres II are a promising carrier as sustained release for pulmonary delivery.

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Authors and Affiliations

  1. College of Marine Life Science, Ocean University of China, Qingdao, 266003, China

    Weifen Zhang  (张维芬), Xiguang Chen  (陈西广), Piwu Li & Huiyun Zhou

  2. Shandong Academy of Food and Fermentation Industries, Jinan, 250013, China

    Piwu Li & Qiangzhi He

  3. Graduate School of Biotechnology, Korea University, Seoul, 136-701, Korea

    Dongsu Cha

  4. Depantment of Pharmacy, Weifang Medical University, Weifang, 261042, China

    Weifen Zhang  (张维芬)

Authors
  1. Weifen Zhang  (张维芬)
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  2. Xiguang Chen  (陈西广)
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  3. Piwu Li
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  4. Qiangzhi He
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  5. Huiyun Zhou
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Corresponding author

Correspondence to Xiguang Chen  (陈西广).

Additional information

Funded by the National Natural Science Foundation of China (No. 30670566) and Natural Science Foundation of Shandong Province

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Zhang, W., Chen, X., Li, P. et al. Chitosan and β-cyclodextrin microspheres as pulmonary sustained delivery systems. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 23, 541–546 (2008). https://doi.org/10.1007/s11595-006-4541-9

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  • DOI: https://doi.org/10.1007/s11595-006-4541-9

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