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The impact of mutual interactions between ZIFs-MWCNTs and hemoglobin molecule on electrocatalysis on hydrogen peroxide reduction of integrated heme protein

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Abstract

This study proposes a composite consisting of zinc-heteroaromatic chemical framework material and hollow carbon-based material, designed to host hemoglobin. A heme protein-based electrode is developed using the complex with protein entrapment. The competitive coordination of heme protein with carbon-based carrier results in a novel intermediate with distinctive spectrometric and electrochemical features. The interaction between redox protein supporter and heme protein would give birth to the predominant influences the configuration of the cofactor within the protein. The article elucidates the role of the intermediate species in heme protein-induced electrocatalysis. Two simultaneous redox processes occur on the heme protein-based electrode. The intermediate species exhibits the favorable heterogeneous electron transfer dynamics (the normalized rate constant: 4.2 s−1). The analysis in the enzyme-involved electro-catalysis suggests that the substrate diffusion dominates the sensing efficiency of the electrochemical sensor.

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Data availability

The data to support the findings of the investigation are available on request from the corresponding author, Han ZENG, upon reasonable request.

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Acknowledgements

The project is financially subsidized by the second batch of innovative environment construction projects of 2022 annual Xin-Jiang Uygur autonomous region natural science foundation general program (2022D01A209).

Funding

The second batch of Innovative Environment Construction Projects of 2022 annual Xin-Jiang Uygur Autonomous Region Natural Science Foundation General Program (2022D01A209).

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  1. Xinjiang Key Laboratory of Energy Storage and Photoelectrocatalytic Materials, Chemistry and Chemical Engineering Academy, XinJiang Normal University, Urumuqi, 830054, XinJiang Uyghur Autonomous Region, People’s Republic of China

    Shi Yu Ying, Xue Qing Chu & Han Zeng

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Shi Yu YING implements the additional supplements of experimental data to consolidate the conclusions in the manuscript. She also participates in the analysis to the electrochemical data and the main deduction in the submission. Xue Qing CHU provides most data of spectrometric and electrochemical experiments. She makes the relevant explanation. Han ZENG is responsible for the sections of the abstract and the conclusion. He contributes to the preparation of the whole framework in the main manuscript text and gets involved in the data analysis. all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Han Zeng.

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Ying, S.Y., Chu, X.Q. & Zeng, H. The impact of mutual interactions between ZIFs-MWCNTs and hemoglobin molecule on electrocatalysis on hydrogen peroxide reduction of integrated heme protein. Ionics 30, 2299–2312 (2024). https://doi.org/10.1007/s11581-024-05389-5

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