, Volume 24, Issue 5, pp 1487–1495 | Cite as

Simultaneous voltammetric determination of droxidopa, acetaminophen, and tyrosine on hematoxylin and graphene oxide/ZnO nanocomposite-modified glassy carbon electrode

  • Hadi Beitollahi
  • Hadiseh Salimi
  • Mohammad Reza Ganjali
Original Paper


Hematoxylin was used in combination with graphene oxide/ZnO nanocomposites as the adhesives for fabricating sensitivity-enhanced electrochemical droxidopa sensor. The electrochemical method showed an excellent character for electrocatalytic oxidization of droxidopa in the presence of acetaminophen and tyrosine. In addition, the experimental parameters such as pH values and the scan rate were optimized. Due to the fine characteristics of modified electrode, a good linear relationship between the anodic peak current and droxidopa concentration in the range 0.075–800.0 μM was observed. The detection limit (3σ) obtained by square wave voltammetry was 4.5 × 10−8 M (S/N = 3). This modified electrode showed excellent selectivity for the determination of droxidopa in the presence of acetaminophen and tyrosine. The prepared sensor was used for determination of droxidopa, acetaminophen, and tyrosine in the real samples.


Droxidopa Acetaminophen Tyrosine Hematoxylin Glassy carbon electrode 


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Hadi Beitollahi
    • 1
  • Hadiseh Salimi
    • 2
  • Mohammad Reza Ganjali
    • 3
    • 4
  1. 1.Environment Department, Institute of Science and High Technology and Environmental SciencesGraduate University of Advanced TechnologyKermanIran
  2. 2.Department of ChemistryGraduate University of Advanced TechnologyKermanIran
  3. 3.Center of Excellence in ElectrochemistryUniversity of TehranTehranIran
  4. 4.Biosensor Research Center, Endocrinology and Metabolism Molecular–Cellular Sciences InstituteTehran University of Medical SciencesTehranIran

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