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Ionics

, Volume 24, Issue 4, pp 1253–1263 | Cite as

Simultaneous electrochemical determination of isoniazid and ethambutol using poly-melamine/electrodeposited gold nanoparticles modified pre-anodized glassy carbon electrode

  • Zahra Sepehri
  • Hasan Bagheri
  • Elias Ranjbari
  • Mohaddeseh Amiri-Aref
  • Salimeh Amidi
  • Mohammad Reza Rouini
  • Yalda Hosseinzadeh Ardakani
Original Paper

Abstract

For the first time, simultaneous voltammetric determination of two kinds of the first-line categorized anti-tuberculosis drugs including isoniazid (INZ) and ethambutol (EBL) was reported at a highly sensitive electrochemical sensor. The proposed sensor was successfully prepared based on an electroactive poly-melamine film and electrodeposited gold nanoparticles (PMel-Aunano)-modified pre-anodized glassy carbon electrode (GCE*). The morphological and electrochemical characteristics of the sensing surface (PMel-Aunano/GCE*) was well-characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The PMel-Aunano/GCE* exhibited strongly catalytic activity toward the oxidation of INZ (0.39 V potential shift) and EBL (0.29 V potential shift) in comparison with PMel/GCE* and bare GCE. Differential pulse voltammograms of INZ and EBL depicted the linear responses with their concentrations at the ranges of 0.3 to 170.0 μM and 0.5 to 150.0 μM, respectively. The detection limits for INZ and EBL were sequentially estimated as 0.08 and 0.21 μM. Furthermore, the developed electrochemical sensor was successfully implemented for the determination of INZ and EBL in real samples using standard addition method. This fabricated sensor showed to be promising for INZ and EBL detection with many desirable features including high-sensitivity, low detection limit, decrease in over-voltage, reproducible responses, and acceptable anti-interferences ability.

Keywords

Electrocatalytic oxidation Simultaneous determination Poly-melamine Gold nanoparticles Isoniazid and ethambutol 

Notes

Acknowledgements

The authors gratefully acknowledge the support provided by the Researches Council of Zabol Medical Science University.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Zahra Sepehri
    • 1
  • Hasan Bagheri
    • 2
  • Elias Ranjbari
    • 3
  • Mohaddeseh Amiri-Aref
    • 3
  • Salimeh Amidi
    • 4
  • Mohammad Reza Rouini
    • 3
  • Yalda Hosseinzadeh Ardakani
    • 3
  1. 1.Department of Internal MedicineZabol University of Medical SciencesZabolIran
  2. 2.Chemical Injuries Research CenterBaqiyatallah University of Medical SciencesTehranIran
  3. 3.Biopharmaceutics and Pharmacokinetics Division, Department of Pharmaceutics, Faculty of PharmacyTehran University of Medical SciencesTehranIran
  4. 4.Department of Medicinal Chemistry, School of PharmacyShahid Beheshti University of Medical SciencesTehranIran

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