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ZnO nanoparticle-modified ionic liquid-carbon paste electrodefor voltammetric determination of folic acid in food and pharmaceutical samples

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Abstract

In this work, a ZnO/nanoparticles (NPs) modified carbon ionic liquid paste electrode (ZnO/NP/CILPE) was fabricated and used to investigate the electrochemical behavior of folic acid. ZnO/NP/CILPE was prepared by mixing hydrophilic ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([C4mim]-[PF6])), ZnO/NPs, graphite powder, and liquid paraffin together. The fabricated ZnO/NP/CILPE showed great electrocatalytic ability to the oxidation of folic acid, and an irreversible oxidation peak appeared at 0.75 V (vs. Ag/AgCl) with improved peak current. Under the optimized conditions of pH 9.0, the plot of peak current vs. folic acid concentration consisted of two linear segments with slopes of 1.776and 0.033 μA/μM in the concentration ranges of 0.05–1.5 μM and 1.5–550.0 μM, respectively. The detection limit was 0.01 μM (3σ). The proposed sensor was successfully applied for the determination of folic acid in fortified food and pharmaceutical samples.

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Acknowledgments

The authors wish to thank the Takestan Branch, Islamic Azad University, for their support.

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Authors and Affiliations

  1. Department of Physics, Takestan Branch, Islamic Azad University, Takestan, Iran

    Ali Taherkhani

  2. Department of Food Science, Science and Research Branch, Islamic Azad University, Mazandaran, Iran

    Tahoora Jamali

  3. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran

    Hassan Hadadzadeh

  4. Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran

    Hassan Karimi-Maleh

  5. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Hadi Beitollahi

  6. Polymer Chemistry Research Laboratory, Department of Chemistry, University of Mazandaran, Babolsar, 47416-95447, Iran

    Mehdi Taghavi

  7. Department of Chemistry, Science and Research Branch, Islamic Azad University, Mazandaran, Iran

    Fatemeh Karimi

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  1. Ali Taherkhani
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  2. Tahoora Jamali
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  3. Hassan Hadadzadeh
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  4. Hassan Karimi-Maleh
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  5. Hadi Beitollahi
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  6. Mehdi Taghavi
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  7. Fatemeh Karimi
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Correspondence to Ali Taherkhani or Fatemeh Karimi.

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Taherkhani, A., Jamali, T., Hadadzadeh, H. et al. ZnO nanoparticle-modified ionic liquid-carbon paste electrodefor voltammetric determination of folic acid in food and pharmaceutical samples. Ionics 20, 421–429 (2014). https://doi.org/10.1007/s11581-013-0992-0

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  • DOI: https://doi.org/10.1007/s11581-013-0992-0

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