Determination of three analgesics in pharmaceutical and urine sample on nano poly (3, 4-ethylenedioxythiophene) modified electrode


Three analgesics, acetaminophen, acetylsalicylic acid, and dipyrone were determined by stripping voltammetry using nanosized poly(3,4-ethylenedioxythiophene)-modified glassy carbon electrode . The cyclic voltammetric behavior of the three analgesics was studied in aqueous acid, neutral, and alkaline conditions. One well-defined oxidation peak each for acetaminophen and acetylsalicylic acid and three oxidation peaks for dipyrone were observed in the cyclic voltammograms. The influence of pH, scan rate, and concentration revealed irreversible diffusion controlled reaction. A systematic study of the experimental parameters that affect the differential pulse stripping voltammetric response was carried out. Calibration was made under maximum peak current conditions. The scanning electron microscope analysis confirmed good accumulation of the drugs on the electrode surface. The range of study for both acetaminophen, acetylsalicylic acid were 0.015–0.4 and dipyrone was 0.025–0.4 μg/ml. The lower limit of determination for both acetaminophen, acetylsalicylic acid was 0.01 μg/mL and for dipyrone was 0.02 μg/mL. The suitability of the method for the determination of the three analgesics in pharmaceutical preparations and urine samples was also ascertained.

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Correspondence to Gopalakrishnan Gopu.

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Gopu, G., Muralidharan, B., Vedhi, C. et al. Determination of three analgesics in pharmaceutical and urine sample on nano poly (3, 4-ethylenedioxythiophene) modified electrode. Ionics 18, 231–239 (2012).

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  • Acetaminophen
  • Acetylsalicylic acid
  • Dipyrone
  • Nano Poly (3,4-ethylenedioxythiophene)
  • Cyclic voltammetry
  • Stripping voltammetry