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Effects of exercise programs on neuroelectric dynamics in drug addiction

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Abstract

Exercise interventions have been considered to be an effective treatment for drug addiction. However, there is little dirct evidence that exercise affects brain activity in individuals afftected by drug addiction. Therefore, the aim of the present study was to investigate the effects of different exercise programs on detoxification. Cognitive recovery with 64-channel electroencephalography (EEG) recordings was obtained before and after three months of daily aerobic and anaerobic exercise. A total of 63 subjects with methamphetamine addiction were recruited and randomly divided into three groups for cognitive study in four behavioral states: an anaerobic resistance treatment group, an aerobic cycling treatment group and a control group. In addition, four behavioral states were examined: eyes-closed and eyes-open resting states, and exploratory behavior states following either drug- or neutral-cue exposure. Over a 12-week period,the alpha block ratio in the control group showed a slight decrease, while clear increases were observed in the resistance exercise and cycling treatment groups, particularly under the frontal and temporal regions in the eyes-open and drug-cue conditions. The major EEG activity frequency in the resistance treatment group during the drug-cue behavior task decreased compared with the frequencies of the cycling exercise and control groups. Meanwhile, the power of higher brain rhythms in the resistance treatment group was increased. Finally, the brain alpha wave left-lateralization index from EEG recording sites, F1–F2, in the resistance and cycling treatment groups under the eyes-closed condition positively decreased, while the control groups only showed slight decreases. Taken together, these results suggest that different types of exercise may induce distince and different positive therapeutic effects to facilitate detoxification.

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Acknowledgements

YY thanks for the support from the National Natural Science Foundation of China (81761128011), Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01) and ZJLab, the program for the Professor of Special Appointment (Eastern Scholar SHH1140004) at Shanghai Institutions of Higher Learning. CZ thanks for the support from National Social Science Foundation of China (17ZDA330).

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Author notes

  1. Yingzhi Lu and Xiaoying Qi have contributed equally to this work.

Authors and Affiliations

  1. School of Psychology, Shanghai University of Sport, Shanghai, 200438, China

    Yingzhi Lu, Qi Zhao, Yifan Chen, Xiawen Li, Yuguo Yu & Chengling Zhou

  2. State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Life Science and Human Phenome Institute, Institutes of Brain Science, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China

    Xiaoying Qi & Yuguo Yu

  3. College of Information Science and Engineering, Xinjiang University, Xinjiang, 830046, China

    Yanjiang Liu

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  1. Yingzhi Lu
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  2. Xiaoying Qi
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  3. Qi Zhao
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  4. Yifan Chen
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Contributions

C.Z and Y.Y. supervised the research, Y.L., Y.C., Q.Z. Y.Y. and C.Z. designed the research, Y.L., Q.Z., Y.C., Q.X., Y.L., and X.L. performed the research, Q.X., Y.L., Y.C., Y.L., and Y.Y. wrote the analysis tools and analysed the data, Y.L., Q.X., Q.Z., Y.C., Y.L., X.L., Y.Y. and C.Z. wrote the paper.

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Correspondence to Yuguo Yu or Chengling Zhou.

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Lu, Y., Qi, X., Zhao, Q. et al. Effects of exercise programs on neuroelectric dynamics in drug addiction. Cogn Neurodyn 15, 27–42 (2021). https://doi.org/10.1007/s11571-020-09647-w

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