Controlling mechanism of absence seizures by deep brain stimulus applied on subthalamic nucleus
- 197 Downloads
Based on a classical model of the basal ganglia thalamocortical network, in this paper, we employed a type of the deep brain stimulus voltage on the subthalamic nucleus to study the control mechanism of absence epilepsy seizures. We found that the seizure can be well controlled by turning the period and the duration of current stimulation into suitable ranges. It is the very interesting bidirectional periodic adjustment phenomenon. These parameters are easily regulated in clinical practice, therefore, the results obtained in this paper may further help us to understand the treatment mechanism of the epilepsy seizure.
KeywordsSWDs Subthalamic nucleus DBS
This research was supported by the National Science Foundation of China (Grant No. 11602092); The Fundamental Research Funds for the Central Universities (Grant No. 2662015QD040) and The National Undergraduate Training Program for Innovation and Entrepreneurship of Huazhong Agricultural University (Grant No. 201710504092).
- Chabards S, Kahane P, Minotti L, Koudsie A, Hirsch E, Benabid AL (2002) Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus. Epileptic Disord 4(3):83–93Google Scholar
- Deransart C, Depaulis A (2002) The control of seizures by the basal ganglia? A review of experimental data. Epileptic Disord 4(3):61–72Google Scholar
- Feng L, Liu TT, Ye DW, Qiu Q, Xiang HB, Cheung CW (2014) Stimulation of the dorsal portion of subthalamic nucleus may be a viable therapeutic approach in pharmacoresistant epilepsy: a virally mediated transsynaptic tracing study in transgenic mouse model. Epilepsy Behav 31:114–116CrossRefPubMedGoogle Scholar
- Lee KJ, Jang KS, Shon YM (2006) Chronic deep brain stimulation of subthalamic and anterior thalamic nuclei for controlling refractory partial epilepsy. In: Advances in functional and reparative neurosurgery. Springer Vienna, pp 87–91Google Scholar
- Slaght SJ, Paz T, Mahon S, Maurice N, Charpier S, Deniau JM (2002) Functional organization of the circuits connecting the cerebral cortex and the basal ganglia: implications for the role of the basal ganglia in epilepsy. Epileptic Disord 4(3):9–22Google Scholar
- Sweet JA, Walter BL, Gunalan K, Chaturvedi A, McIntyre CC, Miller JP (2014) Fiber tractography of the axonal pathways linking the basal ganglia and cerebellum in Parkinson disease: implications for targeting in deep brain stimulation. J Neurosurg 120(4):988–996CrossRefPubMedPubMedCentralGoogle Scholar
- van Albada SJ, Robinson PA (2009b) Mean-field modeling of the basal ganglia thalamocortical system. I: firing rates in healthy and parkinsonian states. J TheorBiol 257(4):642–63Google Scholar
- Vonck K, Sprengers M, Carrette E, Dauwe I, Miatton M, Meurs A, Goossens L, Herdt VD, Achten R, Thiery E, Raedt R, Roost DV, Boon P (2013) A decade of experience with deep brain stimulation for patients with refractory medial temporal lobe epilepsy. Int J Neural Syst 23:1250034CrossRefPubMedGoogle Scholar