Abstract
Synaptic strength is modified by the temporal coincidence of synaptic inputs without back-propagating action potentials (BPAPs) in CA1 pyramidal neurons. In order to clarify the interactive mechanisms of associative long-term potentiation (LTP) without BPAPs, local paired stimuli were applied to the dendrites using high-speed laser uncaging stimulation equipment. When the spatial distance between the paired stimuli was <10 micrometer, nonlinear amplification in excitatory postsynaptic potential summation was observed. In the time window from −20 to 20 ms, supralinear amplification was observed. Supralinear amplification was modulated by antagonist of voltage-gated Na+/Ca2+ channels and NMDA-type glutamate receptors. These results are closely related to the spatiotemporal-characteristics of associative LTP without BPAPs. This study proposes an essential aspect of dendritic information processing.
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Acknowledgments
This work was supported by the 21st Century and the Global COE Program at Tamagawa University and Grant-in-Aid for Scientific Research 17021036, 19200014, 21120006 from Ministry of Education, Culture, Sports, Science and Technology of Japan.
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Yoneyama, M., Fukushima, Y., Tsukada, M. et al. Spatiotemporal characteristics of synaptic EPSP summation on the dendritic trees of hippocampal CA1 pyramidal neurons as revealed by laser uncaging stimulation. Cogn Neurodyn 5, 333–342 (2011). https://doi.org/10.1007/s11571-011-9158-9
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DOI: https://doi.org/10.1007/s11571-011-9158-9