Literatur
Aghajan M, Booten SL, Althage M et al (2019) Antisense oligonucleotide treatment ameliorates IFN-gamma-induced proteinuria in APOL1-transgenic mice. JCI Insight 4:
Beckerman P, Bi-Karchin J, Park AS et al (2017) Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nat Med 23:429–438
Egbuna O, Zimmerman B, Manos G et al (2023) Inaxaplin for proteinuric kidney disease in persons with two APOL1 variants. N Engl J Med 388:969–979
Genovese G, Friedman DJ, Ross MD et al (2010) Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329:841–845
Gerstner L, Chen M, Kampf LL et al (2022) Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila. Kidney Int
Johnstone DB, Shegokar V, Nihalani D et al (2012) APOL1 null alleles from a rural village in India do not correlate with glomerulosclerosis. Plos One 7:e51546
Ma L, Chou JW, Snipes JA et al (2017) APOL1 renal-risk variants induce mitochondrial dysfunction. J Am Soc Nephrol 28:1093–1105
Perez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F et al (2005) Apolipoprotein L‑I promotes trypanosome lysis by forming pores in lysosomal membranes. Science 309:469–472
Pollak MR, Friedman DJ (2023) APOL1 and APOL1-associated kidney disease: a common disease, an unusual disease gene—proceedings of the Henry Shavelle professorship. Glomerular Dis 3:75–87
Reeves-Daniel AM, Depalma JA, Bleyer AJ et al (2011) The APOL1 gene and allograft survival after kidney transplantation. Am J Transplant 11:1025–1030
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K. Lang und T. Hermle geben an, dass kein Interessenkonflikt besteht.
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Lang, K., Hermle, T. Inaxaplin als potenzielle Therapie der APOL1-assoziierten Nephropathie. Nephrologie (2024). https://doi.org/10.1007/s11560-024-00721-6
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DOI: https://doi.org/10.1007/s11560-024-00721-6