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Sotrastaurin

Das Ende einer hoffnungsvollen immunsuppressiven Alternative

Sotrastaurin

The end of a hopeful immunosuppressive alternative

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Der Nephrologe Aims and scope

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Literatur

  1. Russ GR,Tedesco-Silva H, Kuypers DR et al (2013) Efficacy of sotrastaurin plus tacrolimus after de novo kidney transplantation: randomized, phase II trial results. Am J Transplant 13(7):1746–1756

    Article  PubMed  CAS  Google Scholar 

  2. Spitaler M, Cantrell DA (2004) Protein kinase C and beyond. Nat Immunol 5(8):785–790

    Article  PubMed  CAS  Google Scholar 

  3. Mecklenbräuker I, Saijo K, Zheng NY et al (2002) Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. Nature 416(6883):860–865

    Article  PubMed  Google Scholar 

  4. Budde K, Sommerer C, Becker T et al (2010) Sotrastaurin, a novel small molecule inhibiting protein kinase C: first clinical results in renal-transplant recipients. Am J Transplant 10(3):571–581

    Article  PubMed  CAS  Google Scholar 

  5. Friman S, Arns W, Nashan B et al (2011) Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients. Am J Transplant 11(7):1444–1455

    Article  PubMed  CAS  Google Scholar 

  6. o A (2013)Transplantation: development of sotrastaurin halted in kidney transplantation. Nat Rev Nephrol 9(7):370

    Google Scholar 

  7. Tedesco-Silva H, Kho MM, Hartmann A et al (2013) Sotrastaurin in calcineurin inhibitor-free regimen using everolimus in de novo kidney transplant recipients. Am J Transplant 13(7):1757–1768

    Article  PubMed  CAS  Google Scholar 

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Einhaltung ethischer Richtlinien

Interessenkonflikt

L.J. Lehner gibt an, dass kein Interessenkonflikt besteht. K. Budde hat finanzielle Unterstützung für Forschungsprojekte, Reisen, Vorträge und Beratertätigkeit von folgenden Firmen erhalten: AiCuris, Astellas, Bristol-Myers Squibb, Hexal, LifeCycle Pharma, Novartis Pharma, Roche AG, Siemens AG, TCL Pharma und Pfizer.

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Correspondence to L.J. Lehner.

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Lehner, L., Budde, K. Sotrastaurin. Nephrologe 8, 428–430 (2013). https://doi.org/10.1007/s11560-013-0782-8

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  • DOI: https://doi.org/10.1007/s11560-013-0782-8

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