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Ischämie-Reperfusions-Schädigung im Rahmen der Nierentransplantation

Die Rolle der Toll-like-Rezeptoren

Ischaemia-reperfusion injury in the context of renal transplantation

The role of Toll-like receptors

  • Nephro molekular
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Literatur

  1. Yamamoto M, Takeda K (2010) Current views of toll-like receptor signaling pathways. Gastroenterol Res Pract 2010:240365

    PubMed  Google Scholar 

  2. Krüger B, Krick S, Dhillon N et al (2009) Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci U S A 106(9):3390–3395

    Article  PubMed  Google Scholar 

  3. Hoffmann U, Bergler T, Rihm M et al (2011) Impact of Toll-like receptor 2 expression in renal allograft rejection. Nephrol Dial Transplant 26(3):1080–1087

    Article  PubMed  CAS  Google Scholar 

  4. Dhillon N, Walsh L, Krüger B et al (2010) A single nucleotide polymorphism of Toll-like receptor 4 identifies the risk of developing graft failure after liver transplantation. J Hepatol 53(1):67–72

    Article  PubMed  CAS  Google Scholar 

  5. Banas MC, Banas B, Hudkins KL et al (2008) TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol 19(4):704–713

    Article  PubMed  CAS  Google Scholar 

  6. Yu L, Wang L, Chen S (2010) Endogenous toll-like receptor ligands and their biological significance. J Cell Mol Med 14(11):2592–2603

    Article  PubMed  CAS  Google Scholar 

  7. Krüger B, Yin N, Zhang N et al (2010) Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation. Eur J Immunol 40(10):2914–2924

    Article  PubMed  Google Scholar 

  8. Gao Q, Ma LL, Gao X et al (2010) TLR4 mediates early graft failure after intraportal islet transplantation. Am J Transplant 10(7):1588–1596

    Article  PubMed  CAS  Google Scholar 

  9. Wu H, Chen G, Wyburn KR et al (2007) TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 117(10):2847–2859

    Article  PubMed  CAS  Google Scholar 

  10. Leemans JC, Stokman G, Claessen N et al (2005) Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 115(10):2894–2903

    Article  PubMed  CAS  Google Scholar 

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Einhaltung der ethischen Richtlinien

Interessenkonflikt. B. Krüger, T. Singer und B.K. Krämer geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Correspondence to B. Krüger.

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Singer, T., Krämer, B. & Krüger, B. Ischämie-Reperfusions-Schädigung im Rahmen der Nierentransplantation. Nephrologe 8, 431–432 (2013). https://doi.org/10.1007/s11560-013-0778-4

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  • DOI: https://doi.org/10.1007/s11560-013-0778-4

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