Skip to main content
Log in

Langzeitüberleben nach akutem Nierenversagen

Long-term survival after acute renal failure

  • Leitthema
  • Published:
Der Nephrologe Aims and scope

Zusammenfassung

Das akute, intensivpflichtige Nierenversagen ist eine Erkrankung mit hoher Sterblichkeit. Es tritt in der Regel als Komplikation einer schwerwiegenden Grunderkrankung auf, kann diese aggravieren und deren Verlauf ungünstig beeinflussen. Wir wissen heute, dass nicht nur das nierenersatzpflichtige akute Nierenversagen, sondern jede Form der Nierenfunktionsstörung mit einem erhöhten Mortalitätsrisiko assoziiert ist. Die akute renale Nierenfunktionsstörung ist somit eine sehr wichtige, leider oftmals unterschätzte klinische Entität. Daten zum Langzeitüberleben von Patienten mit akutem Nierenversagen sowie zur Lebensqualität nach Entlassung aus dem Krankenhaus sind rar. Das Review soll die aktuelle Literaturlage zu diesem Thema darlegen und kritisch betrachten. Wir zeigen, dass das Langzeitüberleben und vor allem die Lebensqualität der betroffenen Patienten trotz der hohen Krankenhaussterblichkeit erstaunlich gut sind.

Abstract

Acute renal failure requiring intensive care treatment is a disease with a high mortality rate. As a rule it occurs as a complication of a severe underlying disease, which can then be aggravated and can unfavorably influence the course of this disease. Nowadays it is well known that not only acute renal failure requiring renal transplantation, but also all types of disturbances of renal function are associated with an increased mortality risk. Acute renal failure is, therefore, a very important but unfortunately often underestimated clinical entity. Data on long-term survival of patients with acute renal failure as well as quality of life after being released from hospital are rare. This review presents and critically considers the current status of the literature on this theme. It will be shown that despite the high in-hospital mortality rate, long-term survival and quality of life of affected patients are remarkably good.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Edbrooke DL, Hibbert CL, Kingsley JM et al (1999) The patient-related costs of care for sepsis patients in a United Kingdom adult general intensive care unit. Crit Care Med 27(9):1760–1767

    Article  PubMed  CAS  Google Scholar 

  2. Ympa YP, Sakr Y, Reinhart K, Vincent JL (2005) Has mortality from acute renal failure decreased? A systematic review of the literature. Am J Med 118(8):827–832

    Article  PubMed  Google Scholar 

  3. Heering P, Morgera S, Schmitz FJ et al (1997) Cytokine removal and cardiovascular hemodynamics in septic patients with continuous venovenous hemofiltration. Intensive Care Med 23(3):288–296

    Article  PubMed  CAS  Google Scholar 

  4. Ronco C, Bellomo R, Homel P et al (2000) Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 356:26–30

    Article  PubMed  CAS  Google Scholar 

  5. Schaefer JH, Jochimsen F, Keller F et al (1991) Outcome prediction of acute renal failure in medical intensive care. Intensive Care Med 17:19–24

    Article  PubMed  CAS  Google Scholar 

  6. Brivet FG, Kleinknecht DJ, Loirat P, Landais PJ (1996) Acute renal failure in intensive care units—Causes, outcome and prognostic factors of hospital mortality: A prospective, multicenter study. French study group on acute renal failure. Crit Care Med 24:192–198

    Article  PubMed  CAS  Google Scholar 

  7. Chertow GM, Soroko SH, Paganini EP et al (2006) Mortality after acute renal failure: models for prognostic stratification and risk adjustment. Kidney Int 70(6):1120–1126

    Article  PubMed  CAS  Google Scholar 

  8. Mehta RL, Pascual MT, Soroko S et al (2004) Program to improve care in acute renal disease. spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 66(4):1613–1621

    Article  PubMed  Google Scholar 

  9. Uchino S, Kellum JA, Bellomo R et al (2005) Beginning and ending supportive therapy for the kidney (BEST Kidney) investigators. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294(7):813–818

    Article  PubMed  CAS  Google Scholar 

  10. Morgera S, Haase M, Kuss T et al (2006) Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failure. Crit Care Med 34(8):2099–2104

    Article  PubMed  CAS  Google Scholar 

  11. Ostermann M, Chang RWS (2007) Acute kidney injury in the intensive care unit according to RIFLE. Crit Care Med 35:1837–1843

    Article  PubMed  Google Scholar 

  12. Cruz DN, Bolgan I, Perazella MA et al (2007) North East Italian Prospective Hospital Renal Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI) Investigators. North East Italian Prospective Hospital Renal Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI): targeting the problem with the RIFLE Criteria. Clin J Am Soc Nephrol 2(3):418–425

    Article  PubMed  Google Scholar 

  13. Abosaif NY, Tolba YA, Heap M et al (2005) The outcome of acute renal failure in the intensive care unit according to RIFLE: model application, sensitivity and predictability. Am J Kidney Dis 46(6):1038–1048

    Article  PubMed  Google Scholar 

  14. Hoste EA, Lameire NH, Vanholder RC et al (2003) Acute renal failure in patients with sepsis in a surgical ICU: Predictive factors, incidence, comorbidity and outcome. J Am Soc Nephrol 14:1022–1030

    Article  PubMed  Google Scholar 

  15. Nash K, Hafeez A, Hou S (2002) Hospital-acquired renal insufficiency. Am J Kidney Dis 39:930–936

    Article  PubMed  Google Scholar 

  16. Liano F, Pascual J (1996) Epidemiology of acute renal failure: A prospective, multicenter, community-based study. Madrid acute renal failure study group. Kidney Int 50:811–818

    Article  PubMed  CAS  Google Scholar 

  17. Manns B, Doig CJ, Lee H et al (2003) Cost of acute renal failure requiring dialysis in the intensive care unit: clinical and resource implications of renal recovery. Crit Care Med 31(2):449–455

    Article  PubMed  Google Scholar 

  18. Hoyt DB (1997) CRRT in the area of cost containment: is it justified? Am J Kidney Dis 30(5 Suppl 4):S102–S104

    Article  PubMed  CAS  Google Scholar 

  19. Fischer MJ, Brimhall BB, Lezotte DC et al (2005) Uncomplicated acute renal failure and hospital resource utilization: a retrospective multicenter analysis. Am J Kidney Dis 46(6):1049–1057

    Article  PubMed  Google Scholar 

  20. Morgera S, Kraft AK, Siebert G et al (2002) Long-term outcomes in acute renal failure patients treated with continuous renal replacement therapies. Am J Kidney Dis 40(2):275–279

    Article  PubMed  Google Scholar 

  21. Morgera S, Schneider M, Neumayer HH (2008) Long-term outcomes after acute kidney injury. Crit Care Med 36(Suppl 4):S193–S197

    Article  PubMed  Google Scholar 

  22. Burdett S, Stewart L, Rydzewska L (2007) Chemotherapy and surgery versus surgery alone in non-small cell lung cancer. Cochrane Database Syst Rev 18(3):CD006157

    Google Scholar 

  23. Thompson AM, Rapson T, Gilbert FJ, Park KG (2007) Scottish audit of gastric and oesophageal cancer. hospital volume does not influence long-term survival of patients undergoing surgery for oesophageal or gastric cancer. Br J Surg 94(5):578–584

    Article  PubMed  CAS  Google Scholar 

  24. Schiffl H, Fischer R (2008) Five-year outcomes of severe acute kidney injury requiring renal replacement therapy. Nephrol Dial Transplant 23(7):2235–2241 (Epub 2008 Apr 11)

    Article  PubMed  Google Scholar 

  25. Gopal I, Bhonagiri S, Ronco C, Bellomo R (1997) Out of hospital outcome and quality of life in survivors of combined acute multiple organ and renal failure treated with continuous venovenous hemofiltration/hemodiafiltration. Intensive Care Med 23:766–772

    Article  PubMed  CAS  Google Scholar 

  26. Ahlstrom A, Tallgren M, Peltonen S et al (2005) Survival and quality of life of patients requiring acute renal replacement therapy. Intensive Care Med 31:1222–1228

    Article  PubMed  Google Scholar 

  27. Korkeila M, Ruokonen E, Takala J (2000) Costs of care, long-term prognosis and quality of life in patients requiring renal replacement therapy during intensive care. Intensive Care Med 26:1824–1831

    Article  PubMed  CAS  Google Scholar 

  28. Vieira JM Jr, Castro I, Curvello-Neto A et al (2007) Effect of acute kidney injury on weaning from mechanical ventilation in critically ill patients. Crit Care Med 35:184–191

    Article  PubMed  Google Scholar 

  29. Fischer MJ, Brimhall BB, Lezotte DC et al (2005) Uncomplicated acute renal failure and hospital resource utilization: a retrospective multicenter analysis. Am J Kidney Dis 46(6):1049–1057

    Article  PubMed  Google Scholar 

  30. Liangos O, Wald R, O’Bell JW et al (2006) Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. Clin J Am Soc Nephrol 1(1):43–51

    Article  PubMed  Google Scholar 

  31. Welten GM, Schouten O, Chonchol M et al (2007) Temporary worsening of renal function after aortic surgery is associated with higher long-term mortality. Am J Kidney Dis 50(2):219–228

    Article  PubMed  Google Scholar 

  32. Uchino S, Bellomo R, Goldsmith D et al (2006) An assessment of the RIFLE criteria for acute renal failure in hospitalized patients. Crit Care Med 34(7):1913–1917

    Article  PubMed  Google Scholar 

  33. Bagshaw SM, Mortis G, Doig CJ et al (2006) One-year mortality in critically ill patients by severity of kidney dysfunction: a population-based assessment. Am J Kidney Dis 48(3):402–409

    Article  PubMed  Google Scholar 

  34. Kellum JA, Bellomo R, Ronco C (2007) The concept of acute kidney injury and the RIFLE criteria. Contrib Nephrol 156:10–16

    Article  PubMed  Google Scholar 

  35. Mehta RL, Kellum JA, Shah SV et al (2007) The acute kidney injury network. acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11(2):R31 [Epub ahead of print]

    Article  PubMed  Google Scholar 

  36. Kellum JA, Ronco C, Mehta R, Bellomo R (2005) Consensus development in acute renal failure: The acute dialysis quality initiative. Curr Opin Crit Care 11(6):527–532

    Article  PubMed  Google Scholar 

  37. Thompson MJ, Elton RA, Mankad PA et al (1997) Prediction of requirement for and outcome of, prolonged mechanical ventilation following cardiac surgery. Cardiovasc Surg 5:376–381

    Article  PubMed  CAS  Google Scholar 

  38. Hein OV, Birnbaum J, Wernecke K et al (2006) Prolonged intensive care unit stay in cardiac surgery: risk factors and long-term-survival. Ann Thorac Surg 81(3):880–885

    Article  PubMed  Google Scholar 

  39. Bashour CA, Yared JP, Ryan TA et al (2000) Long-term survival and functional capacity in cardiac surgery patients after prolonged intensive care. Crit Care Med 28(12):3847–3853

    Article  PubMed  CAS  Google Scholar 

  40. Jones CH, Richardson D, Goutcher E et al (1998) Continuous venovenous high-flux dialysis in multiorgan failure: a 5-year single-center experience. Am J Kidney Dis 31:227–233

    Article  PubMed  CAS  Google Scholar 

  41. Bhandari S, Turney JH (1996) Survivors of acute renal failure who do not recover renal function. QJM 89:415–421

    PubMed  CAS  Google Scholar 

  42. Luckraz H, Gravenor MB, George R et al (2005) Long and short-term outcomes in patients requiring continuous renal replacement therapy post cardiopulmonary bypass. Eur J Cardio-thoracic Surg 27:906–909

    Google Scholar 

  43. Tian ZM, Miranda DR (1995) Quality of life after intensive care with the sickness impact profile. Intensive Care Med 21:422–428

    Article  PubMed  CAS  Google Scholar 

  44. Brooks R(1996) With the EuroQol Group: EuroQol: the current state of play. Health Policy 37:53–72

    Article  PubMed  CAS  Google Scholar 

  45. Maynard SE, Whittle J, Chelluri L, Arnold R (2003) Quality of life and dialysis decisions in critically ill patients with acute renal failure. Intensive Care Med 29:1589–1593

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Morgera.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morgera, S., Neumayer, H. Langzeitüberleben nach akutem Nierenversagen. Nephrologe 4, 135–141 (2009). https://doi.org/10.1007/s11560-008-0243-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11560-008-0243-y

Schlüsselwörter

Keywords

Navigation