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Ultrasound thermal monitoring with an external ultrasound source for customized bipolar RF ablation shapes

  • Younsu Kim
  • Chloé Audigier
  • Jens Ziegle
  • Michael Friebe
  • Emad M. Boctor
Original Article

Abstract

Purpose

Thermotherapy is a clinical procedure which delivers thermal energy to a target, and it has been applied for various medical treatments. Temperature monitoring during thermotherapy is important to achieve precise and reproducible results. Medical ultrasound can be used for thermal monitoring and is an attractive medical imaging modality due to its advantages including non-ionizing radiation, cost-effectiveness and portability. We propose an ultrasound thermal monitoring method using a speed-of-sound tomographic approach coupled with a biophysical heat diffusion model.

Methods

We implement an ultrasound thermometry approach using an external ultrasound source. We reconstruct the speed-of-sound images using time-of-flight information from the external ultrasound source and convert the speed-of-sound information into temperature by using the a priori knowledge brought by a biophysical heat diffusion model.

Results

Customized treatment shapes can be created using switching channels of radio frequency bipolar needle electrodes. Simulations of various ablation lesion shapes in the temperature range of 21–59 \(^\circ \)C are performed to study the feasibility of the proposed method. We also evaluated our method with ex vivo porcine liver experiments, in which we generated temperature images between 22 and 45 \(^\circ \)C.

Conclusion

In this paper, we present a proof of concept showing the feasibility of our ultrasound thermal monitoring method. The proposed method could be applied to various thermotherapy procedures by only adding an ultrasound source.

Keywords

Thermal monitoring Speed-of-sound reconstruction Ultrasound RFA modeling Bipolar ablation Hyperthermia Ablation therapy Thermotherapy 

Notes

Acknowledgements

The research reported in this paper was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Number R01EB021396 and National Science Foundation under Proposal Number 1653322.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

For this type of study formal consent is not required.

Informed consent

This article does not contain patient data.

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Copyright information

© CARS 2018

Authors and Affiliations

  • Younsu Kim
    • 1
  • Chloé Audigier
    • 1
  • Jens Ziegle
    • 2
  • Michael Friebe
    • 2
  • Emad M. Boctor
    • 1
  1. 1.Johns Hopkins UniversityBaltimoreUSA
  2. 2.Otto-von-Guericke UniversityMagdeburgGermany

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