Experimental investigation of intravascular OCT for imaging of intracranial aneurysms

  • Thomas HoffmannEmail author
  • Sylvia Glaßer
  • Axel Boese
  • Knut Brandstädter
  • Thomas Kalinski
  • Oliver Beuing
  • Martin Skalej
Original Article



Rupture risk assessment of an intracranial aneurysm (IA) is an important factor for indication of therapy. Until today, there is no suitable objective prediction method. Conventional imaging modalities cannot assess the IA’s vessel wall. We investigated the ability of intravascular optical coherence tomography (OCT) as a new tool for the characterization and evaluation of IAs.

Materials and methods

An experimental setup for acquisition of geometrical aneurysm parameters was developed. Object of basic investigation was a silicone phantom with six IAs from patient data. For structural information, three circle of Willis were dissected and imaged postmortem. All image data were postprocessed by medical imaging software.


Geometrical image data of a phantom with six different IAs were acquired. The geometrical image data showed a signal loss, e.g., in aneurysms with a high bottleneck ratio. Imaging data of vessel specimens were evaluated with respect to structural information that is valuable for the characterization of IAs. Those included thin structures (intimal flaps), changes of the vessel wall morphology (intimal thickening, layers), adjacent vessels, small vessel outlets, arterial branches and histological information.


Intravascular OCT provides new possibilities for diagnosis and rupture assessment of IAs. However, currently used imaging system parameters have to be adapted and new catheter techniques have to be developed for a complete assessment of the morphology of IAs.


Intracranial aneurysm wall Optical coherence tomography (OCT) Rupture risk Intracranial arterial wall 



This work was partly funded by the Federal Ministry of Education and Research (BMBF) and Saxony-Anhalt within the Forschungscampus STIMULATE (13GW0095A; I60).

Compliance with ethical standards

Conflict of interest

There is no conflict of interest in this study.


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Copyright information

© CARS 2015

Authors and Affiliations

  • Thomas Hoffmann
    • 1
    Email author
  • Sylvia Glaßer
    • 2
  • Axel Boese
    • 3
  • Knut Brandstädter
    • 4
  • Thomas Kalinski
    • 5
  • Oliver Beuing
    • 1
  • Martin Skalej
    • 1
  1. 1.Institute of NeuroradiologyOtto-von-Guericke UniversityMagdeburgGermany
  2. 2.Department of Simulation and GraphicsOtto-von-Guericke UniversityMagdeburgGermany
  3. 3.Department of Medical EngineeringOtto-von-Guericke UniversityMagdeburgGermany
  4. 4.Institute of Forensic MedicineOtto-von-Guericke UniversityMagdeburgGermany
  5. 5.Institute of PathologyOtto-von-Guericke UniversityMagdeburgGermany

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