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A deformable model for tracking tumors across consecutive imaging studies

International Journal of Computer Assisted Radiology and Surgery volume 4, pages 337–347 (2009)Cite this article

Abstract

Objective

A deformable registration technique was developed and evaluated to track and quantify tumor response to radiofrequency ablation for patients with liver malignancies.

Materials and methods

The method uses the combined power of global and local alignment of pre- and post- treatment computed tomography image data sets. The strategy of the algorithm is to infer volumetric deformation based upon surface displacements using a linearly elastic finite element model (FEM). Using this framework, the major challenge for tracking tumor location is not the tissue mechanical properties for FEM modeling but rather the evaluation of boundary conditions. Three different methods were systematically investigated to automatically determine the boundary conditions defined by the correspondences on liver surfaces.

Results

Using both 2D synthetic phantoms and imaged 3D beef liver data we performed gold standard registration while measuring the accuracy of non-rigid deformation. The fact that the algorithms could support mean displacement error of tumor deformation up to 2 mm indicates that this technique may serve as a useful tool for surgical interventions. The method was further demonstrated and evaluated using consecutive imaging studies for three liver cancer patients.

Conclusion

The FEM-based surface registration technique provides accurate tracking and monitoring of tumor and surrounding tissue during the course of treatment and follow-up.

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Author information

Affiliations

  1. Center for Biomedical Imaging and Informatics, The Cancer Institute of New Jersey, New Brunswick, NJ, USA

    Gabriela Niculescu & David J. Foran

  2. Department of Radiology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA

    John L. Nosher, M. D. Benjamin Schneider & David J. Foran

Authors
  1. Gabriela Niculescu
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  2. John L. Nosher
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  3. M. D. Benjamin Schneider
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  4. David J. Foran
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Corresponding author

Correspondence to Gabriela Niculescu.

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Niculescu, G., Nosher, J.L., Schneider, M.D.B. et al. A deformable model for tracking tumors across consecutive imaging studies. Int J CARS 4, 337–347 (2009). https://doi.org/10.1007/s11548-009-0298-x

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  • DOI: https://doi.org/10.1007/s11548-009-0298-x

Keywords

  • Deformable registration
  • Finite element modeling
  • Radiofrequency ablation