Abstract
Object
A new software module for coronary artery segmentation and visualization in CT angiography (CTA) datasets is presented, which aims to interactively segment coronary arteries and visualize them in 3D with maximum intensity projection (MIP) and volume rendering (VRT).
Materials and Methods
The software was built as a plug-in for the open-source PACS workstation OsiriX. The main segmentation function is based an optimized “virtual contrast injection” algorithm, which uses fuzzy connectedness of the vessel lumen to separate the contrast-filled structures from each other. The software was evaluated in 42 clinical coronary CTA datasets acquired with 64-slice CT using isotropic voxels of 0.3–0.5 mm.
Results
The median processing time was 6.4 min, and 100% of main branches (right coronary artery, left circumflex artery and left anterior descending artery) and 86.9% (219/252) of visible minor branches were intact. Visually correct centerlines were obtained automatically in 94.7% (321/339) of the intact branches.
Conclusion
The new software is a promising tool for coronary CTA post-processing providing good overviews of the coronary artery with limited user interaction on low-end hardware, and the coronary CTA diagnosis procedure could potentially be more time-efficient than using thin-slab technique.
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References
Hoffmann U, Ferencik M, Cury RC, Pena AJ (2006) Coronary CT angiography. J Nucl Med 47: 797–806
Fishman EK, Ney DR, Heath DG, Corl FM, Horton KM, Johnson PT (2006) Volume rendering versus maximum intensity projection in CT angiography: what works best, when, and why. Radiographics 26: 905–922
Leclerc X, Godefroy O, Lucas C, Benhaim JF, Michel TS, Leys D, Pruvo JP (1999) Internal carotid arterial stenosis: CT angiography with volume rendering. Radiology 210: 673–682
van Ooijen PMA, Ho KY, Dorgelo J, Oudkerk M (2003) Coronary artery imaging with multidetector CT: visualization issues. Radiographics 23: e16
Tizon X, Smedby Ö (2002) Segmentation with gray-scale connectedness can separate arteries and veins in MRA. J Magn Reson Imaging 15: 438–445
Löfving A, Tizon X, Persson P, Smedby Ö (2006) Angiographic visualization of the coronary arteries in computed tomography angiography with virtual contrast injection. Int J Radiol 4
Wang C, Smedby Ö (2007) Coronary artery segmentation and skeletonization based on competing fuzzy connectedness tree. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 10: 311–318
Rosset A, Spadola L, Ratib O (2004) OsiriX: an open-source software for navigating in multidimensional DICOM images. J Digit Imaging 17: 205–216
Udupa JK, Saha PK (2003) Fuzzy connectedness and image segmentation. Proc IEEE 91: 1649–1669
Hadwiger M, Berger C, Hauser H (2003) High-quality two-level volume rendering of segmented data sets on consumer graphics hardware. Proc IEEE vis 301–308
Ferencik M, Ropers D, Abbara S, Cury RC, Hoffmann U, Nieman K, Brady TJ, Moselewski F, Daniel WG, Achenbach S (2007) Diagnostic accuracy of image postprocessing methods for the detection of coronary artery stenoses by using multidetector CT. Radiology 243: 696–702
Lei T, Udupa JK, Odhner D, Nyul LG, Saha PK (2003) 3DVIEWNIX-AVS: a software package for the separate visualization of arteries and veins in CE-MRA images. Comput Med Imaging Graph 27: 351–362
Silén C, Wirell S, Kvist J, Nylander E, Smedby Ö Advanced 3D visualization in student-centred medical education. Med Teach (accepted)
Smedby Ö, Wirell S, Kvist J, Silén C, Petersson G, Fyrenius A, Nylander E (2007) Interactive volume rendering 3D images for anatomy learning on low-end computers. ECR -Eur Radiol 17(Suppl 1): 391–392
Florin C, Paragios N, Williams J (2005) Particle filters, a quasi-Monte–Carlo-solution for segmentation of coronaries. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 8: 246–253
Hennemuth A, Boskamp T, Fritz D, Kuhnel C, Bock S, Rinck D, Scheuering M, Peitgen HO (2005) One-click coronary tree segmentation in CT angiographic images. Int Congr Ser 1281: 317–321
Khan MF, Wesarg S, Gurung J, Dogan S, Maataoui A, Brehmer B, Herzog C, Ackermann H, Aβmus B, Vogl TJ (2006) Facilitating coronary artery evaluation in MDCT using a 3D automatic vessel segmentation tool. Eur Radiol 16: 1789–1795
Wang C, Kihlberg J, Persson A, Smedby Ö (2007) Artery-vein separation in vasovist enhanced MR angiograms with virtual contrast injection. In: 19th International workshop on MR angiography, Istanbul
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Wang, C., Frimmel, H., Persson, A. et al. An interactive software module for visualizing coronary arteries in CT angiography. Int J CARS 3, 11–18 (2008). https://doi.org/10.1007/s11548-008-0160-6
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DOI: https://doi.org/10.1007/s11548-008-0160-6