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Impact of temporalis muscle thickness in elderly patients with newly diagnosed glioblastoma treated with radio or radio-chemotherapy

  • Radiotherapy
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Abstract

Background

There is an unmet need for new biomarkers able to predict both the outcomes of up–front therapy and the compliance of elderly patients diagnosed with glioblastoma. For this purpose, temporal muscle thickness is a promising tool to be investigated.

Methods

Data from 52 glioblastoma patients older than 65 years, treated with post-operative radio or radio-chemotherapy and referred to Pisa University Hospital, were retrieved. The thickness of temporal muscle (TMT) was divided into quartiles and correlated with overall survival (Our primary endpoint). Survival curves were calculated using Kaplan–Meier method, and log-rank test was used to evaluate the differences between curves.

Results

Patients in the lower quartile of TMT, with TMT thinner than 7 mm, have survived longer; both univariate and multivariate analyses showed a statistically significant correlation between TMT and overall survival (P = 0.012 and P = 0.003, respectively).

Conclusion

Future prospective and more extensive studies focused on elderly glioblastoma patients are needed to confirm the role of TMT as prognostic value on OS and to help explaining this association.

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Funding

The authors did not receive support from any organization for the submitted work.

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Authors and Affiliations

  1. Oncology Department, Oxford University, Roosevelt Drive, Oxford, OX3 7DQ, UK

    Francesco Pasqualetti

  2. Radiation Oncology Unit, Azienda Ospedaliero Universitaria Pisana, Via Roma 67, 56123, Pisa, Italy

    Francesco Pasqualetti, Alessandra Gonnelli, Martina Cantarella, Sabrina Montrone, Giovanni Gadducci, Noemi Giannini, Roberto Mattioni & Fabiola Paiar

  3. Radiology Unit, Azienda Ospedaliero Universitaria Pisana, Via Roma 67, 56123, Pisa, Italy

    Michela Gabelloni, Lorenzo Faggioni & Emanuele Neri

  4. Neurosurgery Unit, Azienda Ospedaliero Universitaria Pisana, Via Roma 67, 56123, Pisa, Italy

    Nicola Montemurro & Paolo Perrini

  5. Statistic Unit, Azienda Ospedaliero Universitaria Pisana, Via Roma 67, 56123, Pisa, Italy

    Riccardo Morganti

  6. Neuroradiology Unit, Azienda Ospedaliero Universitaria Pisana, Via Roma 67, 56123, Pisa, Italy

    Mirco Cosottini

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  1. Francesco Pasqualetti
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Contributions

All authors whose names appear in this manuscript made substantial contributions to the conception or design of paper, acquisition and interpretation of data, drafted the work or revised it and approved the final version. FP, MG, AG, and FP gave their contribution to set the present study. MG, LF, MC, SM, GG, NG, NM, and PP gave their contributions to data retrievement. FP, FP, NM and EN wrote the present paper. RM, NG, FP and FP performed data analysis.

Corresponding author

Correspondence to Francesco Pasqualetti.

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All authors agreed with the content of the present paper, gave explicit consent to submit and obtained consent from the responsible authorities at the institute/organization where the work has been carried out before the work is submitted. The authors declare that they have no conflicts of interest.

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This article does not contain any studies involving animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Pasqualetti, F., Gabelloni, M., Gonnelli, A. et al. Impact of temporalis muscle thickness in elderly patients with newly diagnosed glioblastoma treated with radio or radio-chemotherapy. Radiol med 127, 919–924 (2022). https://doi.org/10.1007/s11547-022-01524-2

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  • DOI: https://doi.org/10.1007/s11547-022-01524-2

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