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Role of magnetic resonance imaging following postoperative radiotherapy in clinical decision-making of patients with high-grade glioma

  • Radiotherapy
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Abstract

Objectives

The present study aims to investigate the role of the first magnetic resonances (MRI) following radio-chemotherapy (RT-CT) in patients diagnosed with high-grade glioma.

Methods

We retrospectively recorded radiological evaluations following RT-CT, symptoms related to disease progression (avoiding any sign due to radiotherapy or chemotherapy) and the change of therapeutic strategy.

Results

In March 2021, at data analysis, the data of 149 patients diagnosed with high-grade glioma and treated between May 2013 and July 2020 were retrieved for the present analysis. Two out of 122 (1.6%), 5 out of 106 (4.7%) and 8 out of 92 (8.6%) asymptomatic patients received the diagnosis of disease recurrence at the time of the first, second and third MRI, respectively. Otherwise, 16 out of 27 (59.2%), 16 out of 24 (66.6%) and 13 out of 16 (82.2%) symptomatic patients changed their therapy after the first, second and third MRI, respectively. Among patients that experienced radiological signs of distant progression, 10 out of 14 were symptomatic and changed their therapy.

Conclusions

MRIs performed by 6 months after the end of RT-CT lead to change treatment strategy mostly in symptomatic patients.

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Funding

The authors did not receive support from any organization for the submitted work.

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Authors and Affiliations

  1. Radiation Oncology, Department of Translational Medicine, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

    Francesco Pasqualetti, Giulia Malfatti, Martina Cantarella, Alessandra Gonnelli, Sabrina Montrone, Giovanni Gadducci, Noemi Giannini & Fabiola Paiar

  2. Oncology Department, University of Oxford, Oxford, UK

    Francesco Pasqualetti

  3. Department of Neurosurgery, Azienda Ospedaliero Universitaria Pisana (AOUP), Pisa, Italy

    Nicola Montemurro & Paolo Perrini

  4. Department of Translational Research and New Surgical and Medical Technologies, University of Pisa, Pisa, Italy

    Ilaria Pesaresi & Mirco Cosottini

  5. Departmental Section of Statistical Support for Clinical Trials, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy

    Riccardo Morganti

Authors
  1. Francesco Pasqualetti
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  2. Giulia Malfatti
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Contributions

All authors whose names appear on the submission made substantial contributions to the conception or design of the work, or the acquisition, analysis, or interpretation of data; or the creation of new software used in the work; drafted the work or revised it critically for important intellectual content; approved the version to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy.

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Correspondence to Francesco Pasqualetti.

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All authors agreed with the content of the present paper, gave explicit consent to submit and obtained consent from the responsible authorities at the institute/organization where the work has been carried out before the work is submitted. The authors declare that they have no conflicts of interest.

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This article does not contain any studies involving animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Pasqualetti, F., Malfatti, G., Cantarella, M. et al. Role of magnetic resonance imaging following postoperative radiotherapy in clinical decision-making of patients with high-grade glioma. Radiol med 127, 803–808 (2022). https://doi.org/10.1007/s11547-022-01502-8

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