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Increased visceral adipose tissue in male patients with non-clear cell renal cell carcinoma

La radiologia medica volume 125, pages 538–543 (2020)Cite this article

Abstract

Background

It is well known that there is a link between obesity and oncogenesis in many sites, including the kidney. Adiposopathy is characterized by an excessive accumulation of adipose tissue, principally visceral, which can lead to adipocyte and adipose tissue-related disorder, promoting metabolic syndrome. Visceral adipocytes secrete growth factors, proinflammatory cytokines and adipokines, regarded as mediating factors associated with the oncogenesis of obesity-related tumors. In this study, we evaluate the relationship between visceral adipose tissue (VAT) and non-clear cell renal cell carcinoma (nccRCC) in male patients.

Methods

In this retrospective study, two groups were included: nccRCC group and control group. Total adipose tissue (TAT) area, VAT area and subcutaneous adipose tissue (SAT) area were measured in both groups. VAT/SAT ratio was subsequently calculated.

Results

Statistically significant differences between the two groups were found in TAT area (p = 0.05), VAT area (p < 0.01) and VAT/SAT ratio (p < 0.05), while no significant difference was found in SAT area.

Conclusions

This study demonstrates an increased visceral adipose tissue in male patients with nccRCC.

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References

  1. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet (London, England) 371(9612):569–578

    Article  Google Scholar 

  2. World Cancer Research Fund, American Institute for Cancer Research (2007) Food, Nutrition, physical activity and the prevention of cancer: global perspective. American Institute for Cancer Research, Washington, DC

    Google Scholar 

  3. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization technical report series. 894:i–xii, 1–253 (2000)

  4. Park YH, Lee JK, Kim KM, Kook HR, Lee H, Kim KB et al (2014) Visceral obesity in predicting oncologic outcomes of localized renal cell carcinoma. J Urol 192(4):1043–1049

    Article  Google Scholar 

  5. Wozniak SE, Gee LL, Wachtel MS, Frezza EE (2009) Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci 54(9):1847–1856

    Article  Google Scholar 

  6. Ibrahim MM (2010) Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev 11(1):11–18

    Article  Google Scholar 

  7. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY et al (2007) Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 116(1):39–48

    Article  Google Scholar 

  8. Despres JP, Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444(7121):881–887

    CAS  Article  Google Scholar 

  9. Nedungadi TP, Clegg DJ (2009) Sexual dimorphism in body fat distribution and risk for cardiovascular diseases. J Cardiovasc Transl Res 2(3):321–327

    Article  Google Scholar 

  10. Kissebah AH, Vydelingum N, Murray R, Evans DJ, Hartz AJ, Kalkhoff RK et al (1982) Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 54(2):254–260

    CAS  Article  Google Scholar 

  11. Despres JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C (1990) Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis (Dallas, Tex) 10(4):497–511

    CAS  Google Scholar 

  12. Prado CM, Heymsfield SB (2014) Lean tissue imaging: a new era for nutritional assessment and intervention. JPEN J Parenter Enteral Nutr 38(8):940–953

    Article  Google Scholar 

  13. Greco F, Faiella E, Santucci D, Mallio CA, Nezzo M, Quattrocchi CC et al (2017) Imaging of renal medullary carcinoma. J Kidney Cancer VHL 4(1):1–7

    Article  Google Scholar 

  14. Del Buono R, Sabatino L, Greco F (2018) Neck fat volume as a potential indicator of difficult intubation: a pilot study. Saudi J Anaesth 12:67–71

    Article  Google Scholar 

  15. Greco F, Mallio CA, Cirimele V, D’Alessio P, Beomonte Zobel B, Grasso RF (2018) Imaging of renal angiomyolipomatosis. J Ren Hepat Disord 2(2):10–19

    Article  Google Scholar 

  16. Greco F, Mallio CA, Cirimele V, Grasso RF, Beomonte Zobel B (2019) Subcutaneous adipose tissue as a biomarker of pancreatic cancer: a pilot study un male patients. Clin Cancer Investig J 8(3):10–19

    Article  Google Scholar 

  17. Linehan M, Gautam R, Kirk S, Lee Y, Roche C, Bonaccio E et al (2016) Radiology data from the cancer genome atlas cervical kidney renal papillary cell carcinoma [KIRP] collection. Cancer Imaging Arch. https://doi.org/10.7937/K9/TCIA.2016.ACWOGBEF

    Article  Google Scholar 

  18. Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P et al (2013) The Cancer Imaging Archive (TCIA): maintaining and operating a public information repository. J Digit Imaging 26(6):1045–1057

    Article  Google Scholar 

  19. Noumura Y, Kamishima T, Sutherland K, Nishimura H (2017) Visceral adipose tissue area measurement at a single level: can it represent visceral adipose tissue volume? Br J Radiol 90(1077):20170253

    Article  Google Scholar 

  20. Bays HE, Toth PP, Kris-Etherton PM, Abate N, Aronne LJ, Brown WV et al (2013) Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association. J Clin Lipidol 7(4):304–383

    Article  Google Scholar 

  21. Riondino S, Roselli M, Palmirotta R, Della-Morte D, Ferroni P, Guadagni F (2014) Obesity and colorectal cancer: role of adipokines in tumor initiation and progression. World J Gastroenterol 20(18):5177–5190

    CAS  Article  Google Scholar 

  22. Spyridopoulos TN, Petridou ET, Skalkidou A, Dessypris N, Chrousos GP, Mantzoros CS (2007) Low adiponectin levels are associated with renal cell carcinoma: a case-control study. Int J Cancer 120(7):1573–1578

    CAS  Article  Google Scholar 

  23. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257(1):79–83

    CAS  Article  Google Scholar 

  24. Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ et al (2003) Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46(4):459–469

    CAS  Article  Google Scholar 

  25. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Investig 116(7):1784–1792

    CAS  Article  Google Scholar 

  26. Ye J, Jia J, Dong S, Zhang C, Yu S, Li L et al (2014) Circulating adiponectin levels and the risk of breast cancer: a meta-analysis. Eur J Cancer Prev 23(3):158–165

    CAS  Article  Google Scholar 

  27. Hebbard L, Ranscht B (2014) Multifaceted roles of adiponectin in cancer. Best Pract Res Clin Endocrinol Metab 28(1):59–69

    CAS  Article  Google Scholar 

  28. Greco F, Cirimele V, Mallio CA, Beomonte Zobel B, Grasso RF (2018) Increased visceral adipose tissue in male patients with clear cell renal cell carcinoma. Clin Cancer Investig J 7(4):132–136

    Article  Google Scholar 

  29. von Hafe P, Pina F, Perez A, Tavares M, Barros H (2004) Visceral fat accumulation as a risk factor for prostate cancer. Obes Res 12(12):1930–1935

    Article  Google Scholar 

  30. Mallio CA, Greco F, Pacella G, Schena E, Beomonte Zobel B (2018) Gender-based differences of abdominal adipose tissue distribution in non-small cell lung cancer patients. Shanghai Chest. https://doi.org/10.21037/shc.2018.03.03

    Article  Google Scholar 

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Author information

Affiliations

  1. U.O.C. Diagnostica per Immagini Territoriale Aziendale, Cittadella della Salute Azienda Sanitaria Locale di Lecce, Piazza Filippo Bottazzi, 73100, Lecce, Italy

    Federico Greco & Luigi Giuseppe Quarta

  2. Unit of Diagnostic Imaging, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy

    Carlo Augusto Mallio, Raffaele Grippo, Laura Messina, Rosario Francesco Grasso & Bruno Beomonte Zobel

  3. Pathology Unit, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy

    Silvia Vallese & Carla Rabitti

Authors
  1. Federico Greco
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  2. Carlo Augusto Mallio
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  3. Raffaele Grippo
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  4. Laura Messina
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  5. Silvia Vallese
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  6. Carla Rabitti
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  7. Luigi Giuseppe Quarta
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  8. Rosario Francesco Grasso
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  9. Bruno Beomonte Zobel
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Contributions

All authors contributed to the study conception and design. FG conceived and designed the study, carried out statistical analysis, and prepared the manuscript. FG, BBZ, RFG and LGQ defined the intellectual content. CAM and FG performed the literature search. CAM, BBZ and RFG carried out clinical studies. FG and CAM conducted experimental studies. RG, LM and SV took part in data acquisition. FG and CAM analyzed the data. BBZ, RFG, CAM, LGQ and CR edited and reviewed the manuscript. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Federico Greco.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Approval from the Institutional Review Board was not required because this is an observational retrospective study; only existing information collected from human participants is used; and there are not any identifiers linking individual to the data.

Ethical standards

This article does not contain any studies with animals performed by any of the authors. The study was performed in accordance with the Declaration of Helsinki. The Institutional Ethical Committee approved the study. All subjects enrolled provided a written informed consent to use their anonymized data for research purposes.

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Greco, F., Mallio, C.A., Grippo, R. et al. Increased visceral adipose tissue in male patients with non-clear cell renal cell carcinoma. Radiol med 125, 538–543 (2020). https://doi.org/10.1007/s11547-020-01146-6

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  • DOI: https://doi.org/10.1007/s11547-020-01146-6

Keywords

  • Adiposopathy
  • Carcinogenesis
  • Computed tomography
  • Non-clear cell renal cell carcinoma
  • Visceral adipose tissue