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Evaluation of incidence of acute transient dyspnea and related artifacts after administration of gadoxetate disodium: a prospective observational study

  • ABDOMINAL RADIOLOGY
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Abstract

Aims

To evaluate motion artifacts, breath-hold failure, acute transient dyspnea, and clinical parameters during hepatic arterial phase of gadoxetate disodium-enhanced magnetic resonance (MR) imaging.

Methods

This was an institutional review board-approved observational prospective study (written informed consent acquired) performed in 250 consecutive patients, who underwent liver MR with a multiarterial phase technique. Oxygen saturation (SatO2) and heart rate (HR) were monitored, while patients reported subjective symptoms. Breath-holds were assessed using prospective acquisition correction technique (PACE) monitors. Three readers independently analyzed all images to establish the presence of motion artifacts. Nonparametric statistical testing and Fleiss’ kappa were used.

Results

No statistical differences in SatO2 and HR values were observed during the entire length of MR examination. The PACE graphs showed an altered breath-hold in 16/250 patients (6.4%), however only 6 patients self-reported symptoms during the procedure, and among these 6 subjects, only 2 suffered from acute transient dyspnea (0.8%). Motion-related artifacts increased mostly in the third arterial phase of gadoxetate disodium acquisition (p < 0.0001): The artifacts incidence was 2.9% in the first phase; 4.0% in the second; and 19.5% in the third. This increase was mainly due to patients’ inability to hold their breath for the entire duration of the examination. However, at least one gadoxetate disodium arterial phase without motion artifacts and adequate for acquisition timing, was acquired in all MR examinations.

Conclusion

The incidence of breath-hold failure and acute transient dyspnea after gadoxetate disodium administration increased during the third arterial phase only. Our protocol allowed the acquisition of at least one arterial phase not compromised by motion artifacts and adequate for acquisition timing, in all patients.

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Acknowledgements

Authors would like to thank Dr Sara Cortinovis for her invaluable scientific advice and organizational support and Dr Daniela Cigognini for her medical writing support.

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Authors and Affiliations

  1. Department of Radiology, Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy

    Luigi Grazioli, Barbara Frittoli, Roberta Ambrosini & Laura Romanini

  2. Department of Surgical Sciences, Radiology Institute, University of Turin, Via Genova 3, 10126, Turin, Italy

    Riccardo Faletti, Giacomo Battisti, Marco Gatti & Paolo Fonio

Authors
  1. Luigi Grazioli
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  2. Riccardo Faletti
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  3. Barbara Frittoli
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  4. Giacomo Battisti
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  5. Roberta Ambrosini
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  6. Laura Romanini
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  7. Marco Gatti
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  8. Paolo Fonio
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Correspondence to Riccardo Faletti.

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All authors declare that they have no conflicts.

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Grazioli, L., Faletti, R., Frittoli, B. et al. Evaluation of incidence of acute transient dyspnea and related artifacts after administration of gadoxetate disodium: a prospective observational study. Radiol med 123, 910–917 (2018). https://doi.org/10.1007/s11547-018-0927-y

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  • DOI: https://doi.org/10.1007/s11547-018-0927-y

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