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Soft tissue sarcomas in the precision medicine era: new advances in clinical practice and future perspectives

  • Giuseppe Badalamenti
  • Carlo Messina
  • Ida De Luca
  • Emmanuela Musso
  • Alessandra Casarin
  • Lorena Incorvaia
ONCOLOGY IMAGING

Abstract

Soft tissue sarcomas (STSs) represent a rare and heterogeneous group of solid tumours derived from mesenchymal progenitors and account for 1% of all adult malignancies. Although in the last decade anthracycline-based chemotherapy single agent or in combinations has been able to improve clinical benefits, prognosis is still poor and STSs represent an important unmet medical need. Continuous advances in cancer genetics and genomics have contributed to change management paradigms of STSs as it occurred for other solid tumours. Several treatments have been recently developed with the specific aim of targeting different cell pathways and immune-checkpoints that have been recognized to drive tumour progression. The following attempts to provide a review of literature focusing on the available data concerning novel treatments and future prospective for the management of metastatic STSs.

Keywords

Soft tissue sarcomas Immune-checkpoint inhibitors Pembrolizumab Eribulin Olaratumab Targeted therapy 

Notes

Funding

None.

Compliance with ethical standards

Conflict of interest

All authors declare no conflicts of interest.

Ethical approval

This article does not contain any studies with animals or humans performed by any of the authors.

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Copyright information

© Italian Society of Medical Radiology 2018

Authors and Affiliations

  • Giuseppe Badalamenti
    • 1
  • Carlo Messina
    • 2
    • 3
  • Ida De Luca
    • 1
  • Emmanuela Musso
    • 1
  • Alessandra Casarin
    • 1
  • Lorena Incorvaia
    • 1
  1. 1.Section of Medical Oncology, Department of Surgical, Oncological, and Oral SciencesUniversity of PalermoPalermoItaly
  2. 2.Academic Unit of Medical Oncology, Institute for Cancer Treatment and ResearchPoliclinico Hospital San MartinoGenoaItaly
  3. 3.Department of Internal Medicine, School of MedicineUniversity of GenoaGenoaItaly

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