Agitation thrombolysis and catheter-directed thrombolysis for normotensive patients with acute pulmonary thromboembolism
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To assess the feasibility, efficacy, and safety of agitation thrombolysis and catheter-directed thrombolysis (AT–CDT) in the treatment of normotensive patients with acute pulmonary thromboembolism (PTE).
A total of 37 consecutive patients of normotensive PTE were treated by AT–CDT between October 2011 and January 2016. Clinical outcomes and mortality were evaluated after the treatment, and follow-up was carried out after hospital discharge.
AT–CDT was technically successful in 93.7% (36/37) patients, with one case died from respiratory failure during procedure. The clinical success rate was 91.9% (34/37), one patient died from intracranial hemorrhage 9 days after agitation, and one case showed no improvement. A total of 83.8% (31/37) cases were clinical cured and 8.1% (3/37) cases were relieved during hospitalization. Three cases died of respiratory failure caused by PTE, and two cases died of diseases unrelated to PTE (lung carcinoma/hemoptysis) during a 20–1524 days of follow-up.
AT–CDT may be a feasible, effective, and safe treatment for normotensive patients with acute PTE.
KeywordsPulmonary thromboembolism Agitation thrombolysis Catheter-directed thrombolysis Thrombolysis Follow-up
This work was supported by the National Natural Science Foundation of China (Grant No. 81501569) and the National 863 Plan of China (Grant 2015AA020301). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Compliance with ethical standards
Conflict of interest
The authors who have taken part in this study declared that they do not have anything to disclose regarding funding or conflict of interest with respect to this manuscript.
Informed consent was obtained from all individual participants included in the study.
- 2.Kuo WT (2012) Endovascular therapy for acute pulmonary embolism. J Vasc Interv Radiol 23:167–179 e4; quiz 179Google Scholar
- 10.Klevanets J, Starodubtsev V, Ignatenko P, Voroshilina O, Ruzankin P, Karpenko A (2017) Systemic thrombolytic therapy and catheter-directed fragmentation with local thrombolytic therapy in patients with pulmonary embolism. Ann Vasc Surg. https://doi.org/10.1016/j.avsg.2017.05.003 PubMedGoogle Scholar
- 14.Kasper W, Konstantinides S, Geibel A, Olschewski M, Heinrich F, Grosser KD, Rauber K, Iversen S, Redecker M, Kienast J (1997) Management strategies and determinants of outcome in acute major pulmonary embolism: results of a multicenter registry. J Am Coll Cardiol 30:1165–1171CrossRefPubMedGoogle Scholar