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Agitation thrombolysis and catheter-directed thrombolysis for normotensive patients with acute pulmonary thromboembolism

La radiologia medica volume 123, pages 338–344 (2018)Cite this article

Abstract

Objective

To assess the feasibility, efficacy, and safety of agitation thrombolysis and catheter-directed thrombolysis (AT–CDT) in the treatment of normotensive patients with acute pulmonary thromboembolism (PTE).

Methods

A total of 37 consecutive patients of normotensive PTE were treated by AT–CDT between October 2011 and January 2016. Clinical outcomes and mortality were evaluated after the treatment, and follow-up was carried out after hospital discharge.

Results

AT–CDT was technically successful in 93.7% (36/37) patients, with one case died from respiratory failure during procedure. The clinical success rate was 91.9% (34/37), one patient died from intracranial hemorrhage 9 days after agitation, and one case showed no improvement. A total of 83.8% (31/37) cases were clinical cured and 8.1% (3/37) cases were relieved during hospitalization. Three cases died of respiratory failure caused by PTE, and two cases died of diseases unrelated to PTE (lung carcinoma/hemoptysis) during a 20–1524 days of follow-up.

Conclusion

AT–CDT may be a feasible, effective, and safe treatment for normotensive patients with acute PTE.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 81501569) and the National 863 Plan of China (Grant 2015AA020301). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

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Affiliations

  1. Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jian She Road, Zhengzhou, 450052, China

    Yonghua Bi, Zepeng Yu, Xinwei Han & Jianzhuang Ren

  2. Interventional Institute of Zhengzhou University, Zhengzhou, China

    Yonghua Bi, Zepeng Yu, Xinwei Han & Jianzhuang Ren

  3. Interventional Therapy and Clinical Research Center of Henan Province, Zhengzhou, China

    Yonghua Bi, Zepeng Yu, Xinwei Han & Jianzhuang Ren

Authors
  1. Yonghua Bi
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  2. Zepeng Yu
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  3. Xinwei Han
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  4. Jianzhuang Ren
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Corresponding author

Correspondence to Xinwei Han.

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Conflict of interest

The authors who have taken part in this study declared that they do not have anything to disclose regarding funding or conflict of interest with respect to this manuscript.

Ethical approval

Informed consent was obtained from all individual participants included in the study.

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Bi, Y., Yu, Z., Han, X. et al. Agitation thrombolysis and catheter-directed thrombolysis for normotensive patients with acute pulmonary thromboembolism. Radiol med 123, 338–344 (2018). https://doi.org/10.1007/s11547-017-0848-1

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  • DOI: https://doi.org/10.1007/s11547-017-0848-1

Keywords

  • Pulmonary thromboembolism
  • Agitation thrombolysis
  • Catheter-directed thrombolysis
  • Thrombolysis
  • Follow-up