Uterine fibroid embolization efficacy and safety: 15 years experience in an elevated turnout rate center
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To evaluate effectiveness and safety of UFE as alternative to surgery, in treatment of uterine fibromatosis.
255 patients (aged 26–55) with symptomatic UF, indication for surgery, followed in our center (2000–2014), single or multiple fibroids, pain and/or functional/compressive disorders, underwent embolization: injection of PVA particles (150–900 μm) from distal portion of uterine arteries (ascending section). Primary end-point: flow-stop distally to injection site, disappearance of lesion design, preservation of flow in main trunk of UA. Secondary end-point: control of pain and functional/compressive disorders during follow-up (2–7 years).
Procedure was performed bilaterally in 250 patients (98%). Mean duration: 47 min (average fluoroscopy: 10:50 min). Post-embolization pelvic pain (according with VAS score) was on average 2.2 at discharge (24 h). Follow-up at 2 years: resolution of menstrual disorders in 78% of patients and improvement in 14%; pain disappeared in 66%; significant improvement of menstrual flow and HCT/HB levels, decrease in total uterine (57.7%)/dominant fibroid (76.1%) volume. Recurrence in 18 patients.
UFE represents an excellent alternative to surgical treatment: it is safe, tolerable and effective both in short and long term, with evident advantages in economic and social terms.
KeywordsUterine fibroid Uterine fibroid embolization UFE efficacy UFE safety UFE versus surgery
Hormone replacement therapy
Magnetic resonance imaging
Non-steroidal anti-inflammatory drugs
Uterine fibroid embolization
Visual analogue scale
The authors state that this work has not received any funding.
Compliance with ethical standards
The scientific guarantor of this publication is Alessandro Cina, MD.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
One of the authors has significant statistical expertise. The study is on human subjects.
Written informed consent was not required by the Institutional Review Board for this study because it is a retrospective study.
Institutional Review Board approval was not required because is a retrospective study.
Retrospective, observational, performed at one institution.
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