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A prospective study on predicting local recurrence of giant cell tumour of bone by evaluating preoperative imaging features of the tumour around the knee joint

  • ONCOLOGY IMAGING
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An Erratum to this article was published on 01 April 2017

Abstract

Purpose

To evaluate the role of medical imaging in predicting local recurrence of giant cell tumour of bone (GCTB) by assessing the preoperative imaging features of GCTB around the knee.

Methods

Forty-eight consecutive GCTBs in the proximal tibia and distal femur treated with curettage were prospectively enrolled. Patients were grouped in terms of their imaging features on radiography, computed tomography (CT) and magnetic resonance imaging (MRI). All patients were followed up for at least two years after surgery. The association between preoperative imaging features and local recurrence was investigated. Imaging features were retrospectively studied by correlation analysis. The differences between rates were tested by the Chi square and Fisher exact tests; independent factors were determined by multivariate logistic regression analysis.

Results

Cystic change and adjacent soft tissue invasion were associated with a higher rate of local recurrence compared to the negative groups (P < 0.05). Cystic change was identified as an independent risk factor for local recurrence of GCTB (P < 0.05). Expansibility was correlated with the “soap bubble” sign and the fluid–fluid level (P < 0.05); the “soap bubble” sign was correlated with osteosclerosis and the fluid–fluid level (P < 0.05); cortical bone involvement was correlated with adjacent soft tissue invasion (P < 0.05); and cystic change was correlated with the fluid–fluid level (P < 0.05).

Conclusion

Cystic change was an independent risk factor for local recurrence of GCTB. Adjacent soft tissue invasion might indirectly relate to local relapse. A cluster of association relationships between imaging features was revealed.

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Author information

Authors and Affiliations

  1. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197, Rui Jin Er Road, Shanghai, 200025, China

    Yifeng He, Ji Zhang & Xiaoyi Ding

  2. Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Jun Wang

  3. Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Fei Yuan

Authors
  1. Yifeng He
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  2. Jun Wang
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  3. Ji Zhang
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  4. Fei Yuan
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  5. Xiaoyi Ding
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Correspondence to Xiaoyi Ding.

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Funding

This study was funded by the Science and Technology Commission of Shanghai Municipality (Project Number: 134119a2402).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

This article does not contain any studies with human participants or animals performed by any of the authors.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

The original version of this article has been revised: First and last names of the fourth author were incorrect. Now, it has been corrected.

An erratum to this article is available at http://dx.doi.org/10.1007/s11547-017-0760-8.

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He, Y., Wang, J., Zhang, J. et al. A prospective study on predicting local recurrence of giant cell tumour of bone by evaluating preoperative imaging features of the tumour around the knee joint. Radiol med 122, 546–555 (2017). https://doi.org/10.1007/s11547-017-0745-7

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  • DOI: https://doi.org/10.1007/s11547-017-0745-7

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