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Gd-EOB-DTPA-enhanced MRI T1 mapping for assessment of liver function in rabbit fibrosis model: comparison of hepatobiliary phase images obtained at 10 and 20 min

  • Abdominal Radiology
  • Published:
La radiologia medica Aims and scope Submit manuscript

Abstract

Objectives

To compare hepatobiliary phase (HBP) images obtained at 10 and 20 min after Gd-EOB-DTPA-enhanced MRI for assessment of liver function in rabbit fibrosis model on 3.0 T MR imaging.

Methods

34 animals were separated into three groups: 5 for a control group, 14 for a mild fibrosis group, and 15 for a severe fibrosis group based on pathological proof. T1 relaxation times (T1rt) were measured on T1 mapping and reduction rates of T1rt (rrT1rt) were calculated. HBP images were obtained at 10 and 20 min after Gd-EOB-DTPA enhancement. Indocyanine green retention rates at 15 min (ICG R15) were performed for all animals.

Results

T1rt on pre-enhancement imaging showed no significant difference (p > 0.05) among all groups. T1rt on 10 min HBP and 20 min HBP showed significant difference (p < 0.05) among all groups. T1rt and rrT1rt in three groups showed no-significant difference (p > 0.05) between 10 min HBP and 20 min HBP. T1rt on both 10 and 20 min HBP showed significant correlation with ICG R15 (p < 0.05); rrT1rt on both 10 min HBP and 20 min HBP showed significant inverse correlation with ICG R15 (p < 0.05).

Conclusions

Comparing 10 min HBP and 20 min HBP T1 mapping after Gd-EOB-DTPA enhancement, our results suggest that 10 min HBP T1 mapping is feasible for quantitatively assessing liver function.

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Abbreviations

CNR:

Contrast-to-noise ratio

Gd-EOB-DTPA:

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid

HBP:

Hepatobiliary phase

ICG:

Indocyanine green

ICG:

R15 ICG retention rate at 15 min

MRI:

Magnetic resonance imaging

MELD:

Model for end-stage liver disease

ROI:

Region of interest

rrT1rt:

Reduction rate of T1 relaxation time

T1rt T1:

Relaxation time

SI:

Signal intensity

SNR:

Signal-to-noise ratio

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Acknowledgements

Thank you Dr. Kyongtae Bae and Linda Whiting from University of Pittsburgh Medical Centre for giving comments and helping English writing edit.

Funding

This study was funded by the National Natural Science Foundation of China (Grant No. 81260214), and the State Key Program of Health Care of Guangxi (Grant No. 2012080), and the Innovation Project of Guangxi Graduate Education (Grant No. YCBZ2015029).

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Authors and Affiliations

  1. Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, People’s Republic of China

    Zhi-Peng Zhou, Li-Ling Long, Li-Juan Huang, Teng-Fei Yang & Zhong-Kui Huang

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  1. Zhi-Peng Zhou
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Correspondence to Zhong-Kui Huang.

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The authors declare that they have no conflict of interest.

Ethical approval

This prospective study was performed after obtaining approval from the institutional animal review board of Guangxi Medical University. All applicable institutional guidelines for the care and use of animals were followed.

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Zhou, ZP., Long, LL., Huang, LJ. et al. Gd-EOB-DTPA-enhanced MRI T1 mapping for assessment of liver function in rabbit fibrosis model: comparison of hepatobiliary phase images obtained at 10 and 20 min. Radiol med 122, 239–247 (2017). https://doi.org/10.1007/s11547-016-0719-1

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